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- Table of Contents
GIGYF2 Antibodies
AND GIGYF2 ELISA kits, GIGYF2 Proteins
Many biological assays use antibodies to detect GIGYF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GIGYF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GIGYF2 antibodies...
Designing a Western blot for GIGYF2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GIGYF2 Western Blot GuideGIGYF2 Infographic by Boster Bio
All GIGYF2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04303-2
100 μg/vial
Cat # A04303-2
100 μg/vial
GIGYF2 Overview
Facts about GRB10-interacting GYF protein 2.
GRB10-interacting GYF protein 2 (GIGYF2)
Key component of the 4EHP-GYF2 complicated, a multiprotein complex that functions as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, functions as a factor that bridges EIF4E2 into ZFP36/TTP, linking translation repression with mRNA decay (By similarity).
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). .
Gene Information
| Human | |
|---|---|
| Gene Name: | GIGYF2 |
| Uniprot: | Q6Y7W6 |
| Entrez: | 26058 |
Family
| Belongs to: |
|---|
| GIGYF family |
Alternative Names
DKFZp686J17223; FLJ23368; GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 2; GYF domain containing 2; GYF2; KIAA0642DKFZp686I15154; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 2; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; trinucleotide repeat containing 15; Trinucleotide repeat-containing gene 15 protein
Molecular Weight
Mass (kDA):
150.07 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (232697331..232860605) |
Diseases
- Parkinson Disease
- Secondary Parkinson Disease
- Mammary Neoplasms
- Nerve Degeneration
- Essential Tremor
- Malignant Neoplasms
- Resting Tremor
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
- Nervous System Disorder
Pathways
- Pathogenesis
- Transport
- Histone Deacetylation
- Secretory Pathway
- Cell Proliferation
- Hepatocyte Differentiation
- Neuron Differentiation
- Mrna Splicing
- Translation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GIGYF2
bosterbio.com/bosterbio-gene-info-cards/GIGYF2
References
PMID: 12771153 by Giovannone B., et al. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.
PMID: 19279319 by Nichols W.C., et al. Variation in GIGYF2 is not associated with Parkinson disease.