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- Table of Contents
Facts about Glutathione peroxidase 2.
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Human | |
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Gene Name: | GPX2 |
Uniprot: | P18283 |
Entrez: | 2877 |
Belongs to: |
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glutathione peroxidase family |
EC 1.11.1; EC 1.11.1.9; gastrointestinal glutathione peroxidase 2; Gastrointestinal glutathione peroxidase; GIGPX; GI-GPx; glutathione peroxidase 2 (gastrointestinal); Glutathione Peroxidase 2; Glutathione peroxidase-gastrointestinal; Glutathione peroxidase-related protein 2; GPRP; GPRP-2; GPX2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI
Mass (kDA):
21.954 kDA
Human | |
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Location: | 14q23.3 |
Sequence: | 14; NC_000014.9 (64939158..64942745, complement) |
Mostly in liver and gastrointestinal tract, not found in heart or kidney.
Cytoplasm. Mainly cytoplasmic.
Read on to find out more about Boster Bio Antiglutathione Peroxidase 2, GPX2 Marker. This article will discuss Steven Boster's background, the product, as well as the best uses and benefits of the GPX2 Marker. This article will also explain the history of this patented biomarker. You can also find out how you can use this product in your research.
The GPX2 indicator detects the presence glutathione oxidase in human gastrointestinal tract. Glutathione oxidase belongs to the glutathione oxidase enzyme family. It helps protect cells against cellular damage from free radicals. This enzyme reduces hydrogen and lipid peroxides in your body.
GPX1 can be found in most cells and is an important intracellular protein. It works by reducing H2O2 & fatty acids hydroperoxides to alcohols and water. There are eight homologous genes in the human organism. They play an essential role in protecting cells from damage from oxidative Stress.
This antibody detects Glutathione peroxidase 2 in Human, Mouse, and Rat tissues. It is tested by Western Blot. It is compatible with both mouse and rat liver tissue. It is highly specific and can be used to detect the protein in almost any tissue sample. The Boster Bio Anti-Glutathione Peroxidase 2 GPX2 Marker has been used successfully for a variety of applications and is easy to use.
This enzyme catalyzes reactions that neutralize freeradicals. It is the body’s defense mechanism against damage from free-radicals. The enzymes CAT/GPX convert ROS/RNS into a more stable form. To work properly, these enzymes require micronutrients like glutathione (or bile acid).
The mRNA expression of CAT and SOD3 is a function GA. This mRNA Expression marker can be used to measure the level of vital enzymes.
The GPX2 protein encodes glutathione peroxidase 2. This protein protects mammals from cellular damage caused by organic hydroperoxides. GPX2 has the ability to bind to cumene (tert-butylhydrperoxide), cumene (linoleic acid) and cumene. However, it cannot bind phosphatidycholine. These products are manufactured by CUSABIO, a company with strong technical support.
GPX2 is also involved the regulation EMT in cervical tumor cell lines. E-cadherin, Vimentin and Vimentin expression were decreased by GPX2 knockdown. This protein inhibits the migration and invasion of cervical cancer cells. GPX2 inhibition also prevents cervical cancer cells' migration and invasion. These results suggest that GPX2 could be involved in the formation of cervical cancer metastases.
In addition to its role in cervical cancer cell development, GPX2 is also known to inhibit the WNT/b-catenin pathway. This activation could cause changes in other molecules in the pathway. This gene could be used in cancer treatment. If successful, GPX2 Marker application will allow scientists to discover new ways to combat cervical cancer. Read this article to learn more.
PMID: 2388849 by Akasaka M., et al. A human cDNA sequence of a novel glutathione peroxidase-related protein.
PMID: 8428933 by Chu F.-F., et al. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.