This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Glutathione S-transferase A4.
.
Human | |
---|---|
Gene Name: | GSTA4 |
Uniprot: | O15217 |
Entrez: | 2941 |
Belongs to: |
---|
GST superfamily |
DKFZp686D21185; EC 2.5.1.18; glutathione S-alkyltransferase A4; glutathione S-aralkyltransferase A4; glutathione S-aryltransferase A4; glutathione S-transferase A4; Glutathione S-transferase A4-4; glutathione S-transferase alpha 4; glutathione transferase A4-4; GST class-alpha member 4; GSTA4-4; GTA4; S-(hydroxyalkyl)glutathione lyase A4
Mass (kDA):
25.704 kDA
Human | |
---|---|
Location: | 6p12.2 |
Sequence: | 6; NC_000006.12 (52977952..52995332, complement) |
Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Cytoplasm.
This biography can help you learn more about Steven Boster and his life. It includes information about his family, how he discovered the GSTA4 gene and how his research influenced him. Boster is a well-known geneticist whose research is essential for understanding human evolution. The GSTA4 gene is a small genetic coding region in the chromosome. It is located at the junction between the genes GSTA3 and GSTA4, so it is highly likely that the GSTA4 gene is present in your DNA.
In 1993, Steven Boster developed his first product. Boster is known as "the man who converts science into the lavatory", and he created hundreds of primary antibodies and products to use in immunohistochemistry (IHC). Steven Boster, a catalog antibody company based in China, was the company that achieved the greatest success. PicoKine(tm), a proprietary ELISA platform developed by Boster, was used to create high-sensitivity ELISA kit.
Steve Boster was a Joliet native, IL resident, who was born July 6, 1923. He died June 26, 2022 in Madison, WI. He was a former retailer sales manager and proud Concordia Hall, Staunton, VA member. Steve is survived in death by his wife Frances of Verona (WI), his sister Kimberly; his son Jonathan; his granddaughter Cory; and his brother David Boster.
His research on GSTA4 focused on two aspects of CKD, namely its effect on lipid formation and its role in blocking neointima creation. His research suggests that GSTA4 may be crucial in the development neointima. The most common manifestation of CKD is the latter, but it is also a factor for the development of AVF. This is an important component in a healthy, functioning heart.
The GSTA4 marker showed that this enzyme is involved in the removal of reactive amines from the hepatic mitochondria. Mice without this gene have a higher level of protein carbonylation within mitochondria. Additionally, ethanol has been shown in mice to cause liver lipid accumulation and dysregulation of the urea metabolism. While further research is needed, it is clear that GSTA4 is a crucial enzyme in the removal of lipid aldehydes.
PMID: 9461507 by Hubatsch I., et al. Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation.
PMID: 9480897 by Board P.G.; Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.