HIBCH Antibodies

AND HIBCH ELISA kits, HIBCH Proteins

Many biological assays use antibodies to detect HIBCH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HIBCH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HIBCH antibodies...

We validate the specificity of these antibodies to HIBCH by testing them on tissues known to express HIBCH positively and negatively. Browse below to find the HIBCH antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HIBCH Infographic by Boster Bio

All HIBCH Products

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Product

Figures

Specificity

Applications

Price

HIBCH (NM_014362) Human Recombinant Protein

Coomassie blue staining of purified HIBCH protein

$1249
Cat # PROTQ6NVY1
20 µg

Anti-HIBCH Mouse Monoclonal Antibody [Clone ID: OTI3H5]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HIBCH (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-HIBCH monoclonal antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-HIBCH mouse monoclonal antibody

Dog, Human

Flow Cytometry, IHC, WB

$523
Cat # M08660-1
100 µl

Anti-HIBCH Mouse Monoclonal Antibody [Clone ID: OTI4G1]

HEK293T cells transfected with either HIBCH (Myc-DDK-tagged) overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-HIBCH antibody (M08660)

Dog, Human, Monkey, Rat

Flow Cytometry, IF, WB

$523
Cat # M08660
100 µl

HIBCH (NM_014362) Human Over-expression Lysate

Human

$628
Cat # LS026275
20 µg, 100 µg

HIBCH Overview

Facts about 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial.

HIBCH 3D structure. Source: alphafold

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA.

Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

Gene Information

Human
Gene Name:	HIBCH
Uniprot:	Q6NVY1
Entrez:	26275

Family

Belongs to:

enoyl-CoA hydratase/isomerase family

Alternative Names

3-hydroxyisobutyryl-CoA hydrolase; EC 3.1.2.4,3-hydroxyisobutyryl-coenzyme A hydrolase3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; HIB-CoA hydrolase; HIBYLCOAH; HIBYL-CoA-H

Molecular Weight

Mass (kDA):
43.482 kDA

Genomic Context


Human

Location:	2q32.2
Sequence:	2; NC_000002.12 (190203920..190319826, complement)

Tissue Specificity

Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung.

Subcellular Localizations

Mitochondrion.

Diseases

Nerve Degeneration
Neurodegenerative Disorders
Spinocerebellar Ataxia Type 5
Ataxia
Ehlers-danlos Syndrome
Dissection Of Aorta
Loeys-dietz Syndrome
Muscle Hypotonia
Haploinsufficiency
Hypertrophy
Aortic Diseases
Chromosome Breakage

Wallerian Degeneration
Hemochromatosis
Ataxia, Spinocerebellar
Huntington Disease
Ketosis
Marfan Syndrome
Brain Injuries

Pathways

Muscle Hypertrophy
Synaptic Transmission
Pathogenesis

PTMs

Acetylation

Phosphoprotein

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIBCH

References

PMID: 8824301 by Hawes J.W., et al. Primary structure and tissue-specific expression of human beta- hydroxyisobutyryl-coenzyme A hydrolase.

PMID: 17160907 by Loupatty F.J., et al. Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration.