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We validate the specificity of these antibodies to HLA-DQB1 by testing them on tissues known to express HLA-DQB1 positively and negatively. Browse below to find the HLA-DQB1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about HLA class II histocompatibility antigen, DQ beta 1 chain.
The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
|MHC class II family|
CELIAC1; DC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; IDDM1; LB-E12; MB1; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MT1
|Sequence:||6; NC_000006.12 (32659467..32666657, complement)|
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
You aren't the only one curious about BosterBio: Best Uses For The Human HLA–DQB1 marker. Many scientists are just as confused. Boster scientists not only get confused but also their results are often misinterpreted, leading further confusion. How can Boster scientists help you? These are some of the ways that you can use this marker to aid your research.
Boster bio antibodies are used to detect HLA DQB1 in human tissues. This antibody is made from a peptide that comes from the human HLA-DQB1 genome. Its sensitivity is enhanced to a picogram level. Its antibodies can be tested against a variety of samples. They are also quantitatively tested against known amounts of recombinant protein proteins.
The HLA-DQB1 gene contains instructions for making the protein. This gene is an important component of the human immune system (HLA) complex. It helps the body recognize foreign invaders and body proteins. It is unclear if HLA DQB1 is the underlying cause of sarcoidosis.
More studies are demonstrating positive associations between this gene and major infectious diseases. Most of these studies, however, are inconclusive. Nevertheless, major work is needed to provide genetic and functional data substantiating the role of HLA/MHC genes in the susceptibility to various infectious diseases. With the development of new tools and a drop in costs, we expect to see a comprehensive reevaluation of HLA/MHC gene function in the next decade.
The HLA DQB1 gene is a useful marker for genetic admixture research. The desert southwest is home to the HLA-DR variant B*5102. In addition to its high frequency epitope, this gene also serves as an important marker for genetic admixture. Its use can be analyzed in large-scale GWASs.
The Anti-HLA-DQB1*02:01.01 in Boster Bio is a polymerase chain reaction (PCR) product of the human HLA-DQB1*02 gene. The peptide that codes this antibody is derived directly from the human HLA-1 gene's internal region. The length of the antibody will determine whether the antibody can be purchased alone or with a blocking peptide. This method is highly recommended.
The study also revealed a strong association between the HLA–DQB1*02 allele, and NAb seroconversion. The strongest association was seen in HLA-DQB1*02/01, and HLA/DRB1*02/01. This suggests that these alleles play a role in the antigen specific CD4+ T-cell response to JEV. Further studies are needed to clarify the role of HLA-DQB1*02:01 in the antigen-antibody response.
The HLA DQB1*02*01 genes is a gene that provides instructions for making an important protein for the immune. It is part in the human Leukocyte Antigen (HLA), and helps the immune to distinguish between the body’s proteins and those from foreign invaders. The human HLA-DQB1*02.01 gene is an essential component of immune response. However, individuals are highly susceptible to variations.
Using the PyHLA software, the amino acid sequences of all HLA-DQB1*02-01 alleles were aligned. To determine the association between HLA–DQB1*02-01 allele and antibody levels, an analysis of variance was performed (ANOVA). The P-value was 0.05. HLA-DQB1*02.01 and antibody levels were associated in a significant way.
The presence of HLA-DQB1*05.01 in Boster Bio may be due to admixture events with Asian groups. During the colonial period, many Asians came to Mexico, and their ancestry may have contributed to the prevalence of HLA-DQB1*05:01 in Mexican populations. HLA-DQB1*05.01 was also found in East Asians, including Maori from New Zealand. It is also found in populations across the entire Eurasian continent. This has been reported by the Romani of Spain as well as the Czech Republic.
Genomic DNA samples have been adjusted to a 10 ng/mL concentration and then used for real-time real-timePCR assays using Thermo Fisher Scientific Quibit.BR. The Trusight Pre 24 sample kit contained specific primers as well as MasterAmpTM Extra long DNA polymer. The Luminex 200 system was used to analyze the PCR products within 30 minutes.
Boster Bio contains HLA–DQB1*05*01 which increases the likelihood of developing type 1 diabetes. The HLA-DQB1 locus, which is genetically coded with IDDM1 gene, has the highest chance of developing type 1. The late-onset type of diabetes is also linked with the DQB1*0201 Allele. Boster Bio HLA - DQB1*05.01 also shares this risk along with the HLA DR locus and the DR3/DR4 serotypes.
HLA - DQB1*05.02 and MG are strongly linked in certain subtypes. DRB1*16, pMOBP15-36, and MG are not necessarily causal. They could be a susceptibility marker in Italians for MG. To determine if HLA/DQB1*05.02 and MG are related, we need to identify the subtypes that are associated with the disorder.
The humanized MS model is the first to show that pathogenic HLA–DQ-presented Antimyelin Autoimmunity is present. This supports the association between HLA–DQB1*05*02. Further, this association between HLA-DQB1-05:02 and MS is unlikely to be limited to a single genetic variation. There are likely to be many HLA-DQ/DR products implicated in MS, each with a unique set of target Ags.
HLA DQB1*05*02 might be found in Mexican populations. This may be due to admixture between Asian groups. HLA-DRB1*14.54 is a sign of Asian migrants, mainly from the South-East Asian continent. HLA-DQB1*05.02 was also found in some East Asian population, including Maori from New Zealand. HLA - DQB1*05*02 has been found in many parts of the Eurasian area, with frequencies ranging anywhere from 0.0273 to 0.0995.
The results of the study suggest that HLA-DQB1*05*02 may play a role in susceptibility to achalasia. The resulting sequences of mRNA are derived from the genomes of patients with achalasia. However, their CEHs weren't detected in controls. This finding is consistent with previous studies, which indicated that HLA–DQB1*05.02 was a risk factor to achalasia in a variety of Europeans.
The HLA-DRB1 locus, a genetic marker that is associated with the onset and progression of hepatitis C, is found in heterozygous individuals. Since 2003, this marker has been used in research to detect the presence hepatitis C virus. In this study, 161 seropositive patients and -negative patients were genotyped with the HLA–DRB1 locus.
HLA-DRB1 homodimer is composed of two subunits, the alpha and beta chains. It is present on the surface cells of antigen-presenting organisms. It plays an important role in the immune reaction and immune tolerance of human beings. It was previously believed to provide protection against malaria for individuals who had the HLA-DRB1 genetic.
Vaccines represent one of the greatest achievements in the management of infectious disease in the last 300 year. Vaccines cause a humoral immune system response in the recipient. GMT and the rate of seroconversion are two indicators of vaccine effectiveness. IJEV antibody response in Mongolian Chinese is associated with the HLA-DRB1 gene. Although there are a number of studies on the association between HLA-DRB1 and antibody response, this marker has the potential to help determine if vaccines can be more effective in detecting IJEV.
The HLADPB1 marker, also known under the HLA locus, can be used in many areas of healthcare. Its high frequency combined with its low carrier state makes it useful in determining if someone is likely HIV-positive. HLADPB1 is also associated to the BRCA1 Gene. Boster Bio has published several case reports using this marker.
Although the HPV vaccine is relatively new, there have been no vaccinomics studies that have studied HLA-DPB1 marker efficiency. However, it has been shown that the HLA-DPB1 gene and non-HLA gene both play dominant roles in the immune response and are associated with increased risk of developing a disease. Leo et al. It was found that three haplotypes are associated with a higher risk of developing cervical neoplasia following HPV infections. Mainali and colleagues. New susceptibility genes were identified in HPV-16 pathogenesis.
Vaccines have been a major breakthrough in controlling infectious diseases for the past 300 year. It triggers a response in the body that produces NAbs. This response was seen in a Chinese population linked to the HLA-DPB1 gene. The HLA/DPB1 gene was implicated in the IJEV antibody reaction, according to the researchers.