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- Table of Contents
Facts about Minor histocompatibility protein HB-1.
The binding of the peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA- identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants.
Human | |
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Gene Name: | HMHB1 |
Uniprot: | O97980 |
Entrez: | 57824 |
Belongs to: |
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No superfamily |
Minor histocompatibility protein HB-1
Mass (kDA):
4.965 kDA
Human | |
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Location: | 5q31.3 |
Sequence: | 5; NC_000005.10 (143812161..143820716) |
Expressed in acute lymphoblastic leukemia B- cells and Epstein-Barr virus-transformed B-cells.
PMID: 9892612 by Dolstra H., et al. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia.
PMID: 8992968 by Dolstra H., et al. Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.