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- Table of Contents
HTR1B Antibodies
AND HTR1B ELISA kits, HTR1B Proteins
Many biological assays use antibodies to detect HTR1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HTR1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HTR1B antibodies...
Designing a Western blot for HTR1B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HTR1B Western Blot GuideHTR1B Infographic by Boster Bio
All HTR1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01826-2
100 μg/vial
Cat # A01826-2
100 μg/vial
HTR1B Overview
Facts about 5-hydroxytryptamine receptor 1B.
5-hydroxytryptamine receptor 1B (HTR1B)
Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways.
Gene Information
| Human | |
|---|---|
| Gene Name: | HTR1B |
| Uniprot: | P28222 |
| Entrez: | 3351 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
5HT1B; 5-HT1B; 5-HT1B5-HT-1B; 5HT1DB; 5-HT1DB; 5-hydroxytryptamine (serotonin) receptor 1B; HTR1B; HTR1D2; HTR1D2,5-hydroxytryptamine receptor 1B; HTR1DB; S12; S125-HT-1D-beta; Serotonin 1D beta receptor; Serotonin receptor 1B
Molecular Weight
Mass (kDA):
43.568 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q14.1 |
| Sequence: | 6; NC_000006.12 (77460924..77463491, complement) |
Tissue Specificity
Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Migraine Disorders
- Depressive Disorder
- Mental Disorders
- Attention Deficit Hyperactivity Disorder
- Headache
- Pathologic Vasoconstriction
- Dysequilibrium Syndrome
- Anxiety Disorders
- Cancer Patients And Suicide And Depression
- Pain
- Personality Disorders
- Schizophrenia
Interacting Proteins
- MDFI
Pathways
- Vasoconstriction
- Localization
- Pathogenesis
- Secretion
- Vasodilation
- Methylation
- Cell Adhesion
- Vascular Smooth Muscle Contraction
- Muscle Contraction
- Reflex
- Response To Methylphenidate
- Smooth Muscle Contraction
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR1B
bosterbio.com/bosterbio-gene-info-cards/HTR1B
References
PMID: 1315531 by Hamblin M.W., et al. Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5- HT1D-like pharmacological specificity.
PMID: 1610347 by Mochizuki D., et al. Cloning and expression of the human 5-HT1B-type receptor gene.
2 Publications of Boster HTR1B Antibodies & ELISA Kits
- PubMed ID: 10.1111/j.1742-7843.2012.00933.x, Fluoxetine Attenuates Chronic Methamphetamine‐induced Pulmonary Arterial Remod...
- PubMed ID: 30315688, Ren S,Chen M,Yang L,Liu Z.5-Hydroxytryptamine and Dopamine Neurons in the Cerebe...
*More publications can be found for each product on its corresponding product page