5-hydroxytryptamine receptor 1B (HTR1B)

Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways.