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Serine protease HTRA1 Antibodies
AND HTRA1 ELISA kits, Serine protease HTRA1 Proteins
Many biological assays use antibodies to detect Serine protease HTRA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serine protease HTRA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serine protease HTRA1 antibodies...
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HTRA1 Infographic by Boster Bio
All HTRA1 Products
Product
Figures
Specificity
Applications
Price
Anti-HTRA1 Antibody Picoband®
1 Citations 5 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # A01801-1
100 μg/vial
Cat # A01801-1
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01801-1
100 μg
Cat # M01801-1
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01801-2
100 μg
Cat # M01801-2
100 μg
HTRA1 Overview
Facts about Serine protease HTRA1.
Serine protease HTRA1 (HTRA1)
Serine protease with many different targets, including extracellular matrix proteins like fibronectin. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.
During cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the intensity and range of FGF signals in the extracellular space. Regulates the access to insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | HTRA1 |
| Uniprot: | Q92743 |
| Entrez: | 5654 |
Family
| Belongs to: |
|---|
| peptidase S1C family |
Alternative Names
ARMD7; EC 3.4.21; EC 3.4.21.108; High-temperature requirement A serine peptidase 1; HtrA serine peptidase 1; HTRA1; IGFBP5-protease; L56; ORF480; PRSS11; Serine protease 11; serine, 11 (IGF binding)
Molecular Weight
Mass (kDA):
51.287 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.13 |
| Sequence: | 10; NC_000010.11 (122461553..122514907) |
Tissue Specificity
Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).
Subcellular Localizations
Cell membrane. Secreted. Cytoplasm, cytosol. Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635).
Diseases
- Age Related Macular Degeneration
- Exudative Age-related Macular Degeneration
- Blind Vision
- Choroidal Neovascularization
- Neoplasms
- Maculopathy
- Pathologic Neovascularization
- Malignant Neoplasms
- Atrophy
- Geographic Atrophy
- Dysequilibrium Syndrome
- Disorder Of Eye
Interacting Proteins
- THBS1
Pathways
- Pathogenesis
- Localization
- Cell Growth
- Proteolysis
- Cell Death
- Cell Proliferation
- Angiogenesis
- Complement Activation
- Cell Migration
- Eye Development
- Regulation Of Angiogenesis
- Immune Response
- Oxidative Phosphorylation
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTRA1
bosterbio.com/bosterbio-gene-info-cards/HTRA1
References
PMID: 8977104 by Zumbrunn J., et al. Primary structure of a putative serine protease specific for IGF- binding proteins.
PMID: 9852107 by Hu S.I., et al. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage.