HYPK Antibodies

AND HYPK ELISA kits, HYPK Proteins

Many biological assays use antibodies to detect HYPK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HYPK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HYPK antibodies...

We validate the specificity of these antibodies to HYPK by testing them on tissues known to express HYPK positively and negatively. Browse below to find the HYPK antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HYPK Infographic by Boster Bio

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HYPK (NM_016400) Human Over-expression Lysate

Human

$628
Cat # LS025764
20 µg, 100 µg

HYPK Overview

Facts about Huntingtin-interacting protein K.

HYPK 3D structure. Source: alphafold

Huntingtin-interacting protein K (HYPK)

Has a chaperone-like action preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells.

Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation. .

Gene Information

Human
Gene Name:	HYPK
Uniprot:	Q9NX55
Entrez:	25764

Family

Belongs to:

No superfamily

Alternative Names

C15orf63; chromosome 15 open reading frame 63; EC 2.1.1.43; EC 2.7.7.6; FLJ20431; HSPC136; Huntingtin yeast partner K; huntingtin-interacting protein K; HYPKHuntingtin interacting protein K

Molecular Weight

Mass (kDA):
14.665 kDA

Genomic Context


Human

Location:	15q15.3
Sequence:	15; NC_000015.10 (43800421..43804427)

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

Huntington Disease

Interacting Proteins

MAGEA1
NAA15
TXLNA

Pathways

Cell Cycle
Pathogenesis
Cell Cycle Arrest
Translation
Response To Unfolded Protein
Cell Death
Protein Folding

Proteolysis
Cell Growth

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HYPK

References

PMID: 9700202 by Faber P.W., et al. Huntingtin interacts with a family of WW domain proteins.

PMID: 17947297 by Raychaudhuri S., et al. HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity.