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- Table of Contents
4 Citations 4 Q&As
Facts about Interleukin-24.
Human | |
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Gene Name: | IL24 |
Uniprot: | Q13007 |
Entrez: | 11009 |
Belongs to: |
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IL-10 family |
C49A; FISP; IL10B; IL24; IL-24; interleukin 24; MDA-7; MDA7MOB5; melanocyte-associated Mda-7; melanoma differentiation association protein 7; Melanoma differentiation-associated gene 7 protein; MOB-5; ST16; ST16interleukin-24; suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16 protein
Mass (kDA):
23.825 kDA
Human | |
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Location: | 1q32.1 |
Sequence: | 1; NC_000001.11 (206897404..206904139) |
Up-regulated in melanoma cells induced to terminally differentiate.
Secreted.
If you're looking for a high-quality IL24 antibody, you'll want to know about Boster Bio. You can find out more about Boster Bio's applications and optimization tips. Continue reading for more information! We'll also be discussing the various validation methods and platforms used to create Boster Bio's IL24 antibodies. You'll be well-equipped to use their antigens for a variety of applications and research.
Boster Bio Anti-Interleukin-4" IL24 marker uses the human IL-4 gene. The IL-4 Gene consists of one copy, mapped onto chromosome 5.2. The standard product contains 130 amino acids and a molecular mass of 14KDa. The antibody's components are kept at -20°C for a year. The antibody can be used with or without blocking peptide, depending on the size of the immunogen and the number of antibodies required.
Boster Bio provides helpful tips and tricks to optimize your experiments with the IL24 marker. They offer a variety of secondary antibodies and isotype controls. These are designed for maximum IHC results. Boster Bio also provides answers to common questions regarding negative controls. Learn about the techniques and reagents used to optimize experiments with the IL24 mark.
The immune system cells produce the IL24 marker. Its diverse functions include enhancing the innate defense response in epithelial tissues during inflammation and infection. It regulates cellular proliferation and migration and promotes the production of antimicrobial peptides and S100 family proteins, and facilitates recruitment of leukocytes to areas of inflammation. It also helps maintain tissue homeostasis.
In addition to its role in immunopathological diseases, IL-24 has also been associated with the development of inflammatory bowel disease and psoriasis. Despite its many roles in these diseases the IL-24 marker is still one of the most studied markers in these conditions. It can be used in clinical practice in several ways. First, determine if the IL-24 level in a particular tumor is higher than normal.
One method is to modify IL-24. It can be targeted to tumor cells and tissues, and the RGD peptide is a highly conserved motif found on several ligands. The IL-24 coding area can be targeted to avb3 integrin (a marker of neovascularization). ACDCRGDCFCG (RGD-4C) peptide is specifically designed to bind to this integrin.
The IL24 gene is regulated by HMGB1. Both of these pathways regulate the expression of the IL24 gene independent of cytokine signals. These findings are promising, but more research is needed before they can be confirmed. The application of IL24 in clinical settings is an area that urgently needs to be investigated. Its widespread usage will enable researchers and clinicians to develop better treatments for patients suffering from autoimmune disease.
IL-24 is a pleiotropic cytokine that affects several cell populations and displays a broad range of functions. It suppresses keratinocyte growth during wound healing, acts as an anti-tumor agent, and serves many other functions. Depending on the location of the molecule, its activity may vary. In cancer, for instance, IL-24 is a potent antitumor molecule, inducing tumor-specific apoptosis and inhibiting angiogenesis.
IL-24 causes cancer by activating downstream molecules and ER stress. It also regulates angiogenesis as well as invasion and metastasis via activation Fas-FasL. It activates Sigma 1 Receptor (BiP), which is involved in calcium mobilization, and ROS production. Its expression has many clinical and scientific applications. This receptor is also vital in the management of autoimmune diseases.
PMID: 8545104 by Jiang H., et al. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.
PMID: 11704829 by Huang E.Y., et al. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
*More publications can be found for each product on its corresponding product page