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- Table of Contents
Facts about Insulin-like 3.
Is a ligand for LGR8 receptor. .
Human | |
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Gene Name: | INSL3 |
Uniprot: | P51460 |
Entrez: | 3640 |
Belongs to: |
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insulin family |
Insulin-like 3
Mass (kDA):
14.502 kDA
Human | |
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Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (17816512..17821519, complement) |
Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
Secreted.
If you're looking to learn more about Boster Bio: Anti-Bax (Apoptosis Marker) Monoclonal Antibody you've come the right spot. This article covers the application and references for INSL3, which is a monoclonal antibody that targets the marker for apoptosis Bax. Let's get started!
Multiple tests have confirmed the Boster Bio: Anti-Bax and Apoptosis marker Monoclonal Antibody. This antibody is directed against the human Bax protein and reacts with Rat, Mouse, and Human samples. It is also available as an WB antibody. Both of these antibodies can be used in different ways.
The company has been involved in research into immunochemicals for more than a quarter of a century. Its antibodies are validated by multiple platforms using positive and negative samples. They also confirm their high affinity as well as specificity. The Boster Bio: Anti-Bax (Apoptosis Marker), monoclonal antibody can keep at 2-8degC for one week. You can also take aliquots of the antibody to store at -20°C for a longer period of storage. Avoid freezing it in frost-free containers. Mix the solution with care prior to using it.
BAX, which is part of the Bcl-2 protein family, is considered a pro-apoptotic gene. It regulates apoptosis using heterodimerization and homodimerization of various isoforms. The beta and alpha are the two distinct forms of the BAX gene. Each has distinct carboxyl termini and isn't homologous to Bcl-2 alpha. It forms heterodimers as well as homodimers with other BCL-2-related proteins.
The Boster Bio INSL3 antibody monoclonal is validated for use in IHC applications. This antibody reacts with Monkey and Human cells. The INSL3 marker is widely used biomarker used in immunohistochemistry research, as well as molecular biology research. The INSL3 is a specific protein that is found in mitochondria of cells. Multiple assays have validated the Boster Bio INSL3 monoclonal antibodies monoclonal for research.
INSL3 is a unique anabolic impact on bones, especially osteoblasts. Additionally it is highly immunoreactive, making it useful for the detection of disease-related protein levels in blood. Understanding how this protein functions will allow for efficient targeting of this receptor in future applications of therapeutics. Additionally, understanding the mechanisms of signaling that INSL3 follows will help avoid harmful off-target effects. There are a variety of applications for the marker INSL3, ranging from research into drugs to diagnostic tests.
The INSL3 markeris a new chemical, can be used to determine the presence of proteins in the human body. Studies have proven that INSL3 has anti-inflammatory and anti-proliferative properties as well as an effect that reduces inflammation. It also was proven to aid in wound healing. INSL3 is not cross-reactive with other proteins. However it is recommended to dilute it to meet the needs of the user.
The INSL3 gene is expressed throughout adulthood, with a particular focus in the testicles. It is also linked to a variety of other conditions including cancer. InSL3 expression in a variety of organs may indicate that it may have therapeutic implications. Furthermore, INSL3 functions may be involved in other areas of the body, for instance, the health of muscles and bones. Researchers should look into the possibilities for drugs targeted to INSL3 that improve people's quality of life and treat a variety of age-related ailments.
A number of studies have demonstrated that INSL3 is a receptor for the RXFP2 receptor. The receptor has seven transmembrane helical domains and 10 leucine rich repeats. The mature INSL3 hormone is created when the B-chain and A-chain are joined by disulfide links. INSL3's binding location is in the LRR domain. The binding site of the A-chain is located in the extracellular loops that are located in the TM. The Linker region of INSL3 directs the LDLa module toward the TM.
Research studies have shown that INSL3 is not acutely regulated by the hypothalamic-pituitary axis, but rather constitutively secreted by the Leydig cells. Anti-Mullerian hormone production is reduced by androgens in the early stages of testicular development, and prior to puberty. The use of this marker in diagnostic and therapeutic treatment has been linked with a variety of conditions, including hypogonadism. In recent times, however, recent reports indicate that INSL3 plays a part in extragonadal physiology.
PMID: 8034302 by Burkhardt E., et al. A human cDNA coding for the Leydig insulin-like peptide (Ley I-L).
PMID: 8020942 by Burkhardt E., et al. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3).