Inversin Antibodies

AND Invs ELISA kits, Inversin Proteins

Many biological assays use antibodies to detect Inversin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Inversin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Inversin antibodies...

We validate the specificity of these antibodies to Inversin by testing them on tissues known to express Invs positively and negatively. Browse below to find the Invs antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Invs Infographic by Boster Bio

All Invs Products

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Anti-Inversin INVS Antibody

Western blot analysis of extracts of various cell lines, using INVS antibody at 1:1000 dilution

Human, Mouse

$405
Cat # A01628
100ul

Inversin (INVS) (NM_014425) Human Over-expression Lysate

Inversin (INVS) Human Over-expression Lysates NM_014425

Human

$960
Cat # LS027130
20 µg, 100 µg

Invs Overview

Facts about Inversin.

Inversin (Invs)

Required for normal renal development and institution of left-right axis. Probably functions as a molecular switch between distinct Wnt signaling pathways.

Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests it is needed in renal growth to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).

Gene Information

Mouse
Gene Name:	Invs
Uniprot:	O89019
Entrez:	16348

Family

Belongs to:

No superfamily

Alternative Names

Inversin

Molecular Weight

Mass (kDA):
117.129 kDA

Genomic Context


Mouse

Location:	4 B1\|4 26.11 cM
Sequence:	4;

Tissue Specificity

Strongly expressed in the primary cilia of renal cells, especially in the varicosities, swellings observed in the cilia. Localizes in the node monocilia and in other 9+0 monocilia, including those of kidney epithelial cells and the pituitary gland, but it does not localize to 9+2 cilia (at protein level). In adult, it is expressed at high level in liver and kidney. Weakly or not expressed in other tissues.

PTMs

Hydroxylation

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Invs

References

PMID: 9744276 by Mochizuki T., et al. Cloning of inv, a gene that controls left/right asymmetry and kidney development.

PMID: 9771707 by Morgan D., et al. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.