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- Table of Contents
ITPA Antibodies
AND ITPA ELISA kits, ITPA Proteins
Many biological assays use antibodies to detect ITPA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITPA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITPA antibodies...
Designing an IHC experiment for ITPA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ITPA IHC GuideITPA Infographic by Boster Bio
All ITPA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02304
100 µg/vial
Cat # A02304
100 µg/vial
Human
$628
Cat # LS003704
20 µg, 100 µg
Cat # LS003704
20 µg, 100 µg
$1249
Cat # PROTQ9BY32
20 µg
Cat # PROTQ9BY32
20 µg
ITPA Overview
Facts about Inosine triphosphate pyrophosphatase.
Inosine triphosphate pyrophosphatase (ITPA)
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as two'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) for their individual monophosphate derivatives. The enzyme does not distinguish between the deoxy- and - ribose forms.
Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ITPA |
| Uniprot: | Q9BY32 |
| Entrez: | 3704 |
Family
| Belongs to: |
|---|
| HAM1 NTPase family |
Alternative Names
C20orf37; dJ794I6.3; EC 3.6.1; EC 3.6.1.19; HLC14-06-P; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphatase; inosine triphosphatase-A; inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphohydrolase; ITPase; My049 protein; nucleoside triphosphate diphosphatase; Putative oncogene protein hlc14-06-p
Molecular Weight
Mass (kDA):
21.446 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (3208676..3227449) |
Tissue Specificity
Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Subcellular Localizations
Cytoplasm.
Diseases
- Hepatitis C
- Hepatitis
- Anemia
- Hepatitis C, Chronic
- Hepatitis, Chronic
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Medication Reaction
- Learning Disorders
- Anemia, Hemolytic
- Language Disorders
- Language Development Disorders
Pathways
- Localization
- Chromosome Localization
- Response To Methotrexate
- Translation
- Cell Proliferation
- Response To Hypoxia
- Mastication
- Glomerular Filtration
- Methylation
- Dna Replication
PTMs
- Reduction
- Deamination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITPA
bosterbio.com/bosterbio-gene-info-cards/ITPA
References
PMID: 11278832 by Lin S., et al. Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene.
PMID: 17090528 by Burgis N.E., et al. Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.