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- Table of Contents
Facts about Potassium channel subfamily K member 10.
Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. .
Human | |
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Gene Name: | KCNK10 |
Uniprot: | P57789 |
Entrez: | 54207 |
Belongs to: |
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two pore domain potassium channel (TC 1.A.1.8) family |
2P domain potassium channel TREK2; K2p10.1; Outward rectifying potassium channel protein TREK-2; potassium channel subfamily K member 10; potassium channel TREK-2; potassium channel, subfamily K, member 10; TREK-2 K(+) channel subunit; TREK-2; TREK2FLJ43399; TWIK-related K+ channel 2
Mass (kDA):
59.765 kDA
Human | |
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Location: | 14q31.3 |
Sequence: | 14; NC_000014.9 (88180108..88326912, complement) |
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Membrane; Multi-pass membrane protein.
PMID: 10880510 by Lesage F., et al. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors.
PMID: 11897838 by Gu W., et al. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.