KCNK10 Antibodies

AND KCNK10 ELISA kits, KCNK10 Proteins

Many biological assays use antibodies to detect KCNK10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNK10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNK10 antibodies...

We validate the specificity of these antibodies to KCNK10 by testing them on tissues known to express KCNK10 positively and negatively. Browse below to find the KCNK10 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNK10 Infographic by Boster Bio

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KCNK10 (NM_021161) Human Over-expression Lysate

KCNK10 Human Over-expression Lysates NM_021161

Human

$628
Cat # LS054207
20 µg, 100 µg

KCNK10 Overview

Facts about Potassium channel subfamily K member 10.

KCNK10 3D structure. Source: alphafold

Potassium channel subfamily K member 10 (KCNK10)

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating external rectifier K(+) currents.

Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. .

Gene Information

Human
Gene Name:	KCNK10
Uniprot:	P57789
Entrez:	54207

Family

Belongs to:

two pore domain potassium channel (TC 1.A.1.8) family

Alternative Names

2P domain potassium channel TREK2; K2p10.1; Outward rectifying potassium channel protein TREK-2; potassium channel subfamily K member 10; potassium channel TREK-2; potassium channel, subfamily K, member 10; TREK-2 K(+) channel subunit; TREK-2; TREK2FLJ43399; TWIK-related K+ channel 2

Molecular Weight

Mass (kDA):
59.765 kDA

Genomic Context


Human

Location:	14q31.3
Sequence:	14; NC_000014.9 (88180108..88326912, complement)

Tissue Specificity

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Depressive Disorder
Pain
Ischemia
Brain Ischemia
Nervousness
Memory Disorders
Edema
Memory Impairment
Acidosis
Epilepsy
Inflammation
Hypoxia

Cerebrovascular Accident
Chronic Cerebral Ischemia
Cerebral Ischemia
Epilepsy, Temporal Lobe
Colitis
Brain Injuries
Hypoxia-ischemia, Brain

Pathways

Neuroprotection
Translation
Blastocyst Formation
Membrane Depolarization
Cell Growth
Cell Proliferation
Membrane Hyperpolarization
Insulin Secretion
Brain Development
Fertilization
Localization

Mrna Splicing
Reverse Transcription
Cognition
Rna Interference
Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNK10

References

PMID: 10880510 by Lesage F., et al. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors.

PMID: 11897838 by Gu W., et al. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.