KCNMB1 Antibodies

AND KCNMB1 ELISA kits, KCNMB1 Proteins

Many biological assays use antibodies to detect KCNMB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNMB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNMB1 antibodies...

We validate the specificity of these antibodies to KCNMB1 by testing them on tissues known to express KCNMB1 positively and negatively. Browse below to find the KCNMB1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNMB1 Infographic by Boster Bio

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Anti-KCMB1 KCNMB1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A04747
100ul

KCNMB1 Overview

Facts about Calcium-activated potassium channel subunit beta-1.

KCNMB1 3D structure. Source: alphafold

Calcium-activated potassium channel subunit beta-1 (KCNMB1)

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties.

Gene Information

Human
Gene Name:	KCNMB1
Uniprot:	Q16558
Entrez:	3779

Family

Belongs to:

KCNMB (TC 8.A.14.1) family

Alternative Names

BK channel beta subunit; BK channel subunit beta-1; BKbeta; BKbeta1; Calcium-activated potassium channel subunit beta; calcium-activated potassium channel subunit beta-1; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; Maxi K channel beta subunit; Maxi K channel subunit beta-1; potassium large conductance calcium-activated channel, subfamily M, beta member1; Slo-beta; slo-beta-1

Molecular Weight

Mass (kDA):
21.797 kDA

Genomic Context


Human

Location:	5q35.1
Sequence:	5; NC_000005.10 (170374671..170389367, complement)

Tissue Specificity

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Hypertensive Disease
Diastolic Hypertension
Infarction
Cardiovascular Diseases
Myocardial Infarction
Hypoxia
Pathologic Vasoconstriction
Cholangiocarcinoma
Essential Hypertension
Dysequilibrium Syndrome
Stenosis
Cerebrovascular Accident
Asthma

Picornaviridae Infections
Epilepsy, Generalized
Airway Obstruction
Nephrosclerosis
Dyskinetic Syndrome
Dyskinesia, Paroxysmal
Chronic Kidney Disease

Pathways

Chromatin Remodeling
Secretion
Vasodilation
Smooth Muscle Contraction
Cell Proliferation
Membrane Hyperpolarization
Response To Hypoxia
Aging
Osteoblast Proliferation
Synaptic Transmission
Muscle Contraction
Mitochondrial Depolarization
Localization

Glomerular Filtration
Sarcomerogenesis
Membrane Depolarization
Translation
Cell Growth
Pathogenesis
Regulation Of Blood Pressure

PTMs

Glycoprotein

Research Areas

Potassium Channels

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNMB1

References

PMID: 8612769 by Meera P., et al. A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels.

PMID: 8764643 by Dworetzky S.I., et al. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.