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- Table of Contents
KCNQ1 Antibodies
AND KCNQ1 ELISA kits, KCNQ1 Proteins
Many biological assays use antibodies to detect KCNQ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNQ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNQ1 antibodies...
Designing a Western blot for KCNQ1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCNQ1 Western Blot GuideDesigning an IHC experiment for KCNQ1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KCNQ1 IHC GuideKCNQ1 Infographic by Boster Bio
All KCNQ1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00310-1
100 μg/vial
Cat # A00310-1
100 μg/vial
KCNQ1 Overview
Facts about Potassium voltage-gated channel subfamily KQT member 1.
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)
Potassium channel that plays an important role in several of tissues, such as heart, internal ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231).
Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification feature (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNQ1 |
| Uniprot: | P51787 |
| Entrez: | 3784 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
ATFB3; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; JLNS1; KCNA8FLJ26167; KCNA9Kv1.9; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv7.1; KVLQT1ATFB1; LQT; LQT1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS
Molecular Weight
Mass (kDA):
74.699 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5-p15.4 |
| Sequence: | 11; NC_000011.10 (2445008..2849110) |
Tissue Specificity
Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Early endosome. Membrane raft. Endoplasmic reticulum. Basolateral cell membrane. Colocalized with KCNE3 at the plasma membrane (PubMed:10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed:23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed:24855057). During the early stages of epithelial cell polarization induced by the calcium switch it removed from plasma membrane to the endoplasmic reti
Diseases
- Long Qt Syndrome
- Cardiac Arrhythmia
- Sudden Death
- Syncope
- Sudden Cardiac Death
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Long Qt Syndrome Congenital
- Cardiac Fibrillation
- Complete Hearing Loss
- Torsades De Pointes
- Cardiac Death
- Romano-ward Syndrome
Interacting Proteins
- KCNE1
Pathways
- Secretion
- Transport
- Methylation
- Localization
- Acid Secretion
- Pathogenesis
- Gastric Acid Secretion
- Dna Methylation
- Insulin Secretion
- Ion Transport
- Cell Proliferation
- Membrane Depolarization
- Swimming
PTMs
- Methylation
- Phosphorylation
- Reduction
- Glycosylation
- Demethylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNQ1
bosterbio.com/bosterbio-gene-info-cards/KCNQ1
References
PMID: 9312006 by Chouabe C., et al. Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.
PMID: 9305853 by Jiang M., et al. Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart.