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- Table of Contents
KDM1A Antibodies
AND KDM1A ELISA kits, KDM1A Proteins
Many biological assays use antibodies to detect KDM1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM1A antibodies...
Designing a Western blot for KDM1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KDM1A Western Blot GuideDesigning an IHC experiment for KDM1A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KDM1A IHC GuideKDM1A Infographic by Boster Bio
All KDM1A Products
Product
Figures
Specificity
Applications
Price
Anti-KDM1/LSD1 KDM1A Rabbit Monoclonal Antibody
2 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00532-1
100 μl
Cat # M00532-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00532-3
20μL, 40μL, 100μL, 200μL
Cat # M00532-3
20μL, 40μL, 100μL, 200μL
KDM1A Overview
Facts about Lysine-specific histone demethylase 1A.
Lysine-specific histone demethylase 1A (KDM1A)
Histone demethylase that demethylates both'Lys-4' (H3K4me) and'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending upon the context. Followed by oxidizing the substrate by FAD to create the corresponding imine that's subsequently hydrolyzed.
Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. May play a role in the repression of neuronal genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | KDM1A |
| Uniprot: | O60341 |
| Entrez: | 23028 |
Family
| Belongs to: |
|---|
| flavin monoamine oxidase family |
Alternative Names
amine oxidase (flavin containing) domain 2; AOF2; AOF2lysine-specific histone demethylase 1; BHC110; BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; KIAA0601KDM1; LSD1; LSD1BRAF35-HDAC complex protein BHC110; lysine (K)-specific demethylase 1; Lysine (K)specific Demethylase 1A; Lysine (K)-specific Demethylase 1A; lysine-specific histone demethylase 1A
Molecular Weight
Mass (kDA):
92.903 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (23019443..23083691) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Prostatic Neoplasms
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Leukemia, Myelocytic, Acute
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Cell Invasion
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Lung
Pathways
- Methylation
- Demethylation
- Histone Methylation
- Histone Demethylation
- Cell Proliferation
- Cell Cycle
- Histone Modification
- Chromatin Remodeling
- Regulation Of Gene Expression
- Histone Acetylation
- Dna Methylation
- Gene Silencing
- Chromatin Modification
PTMs
- Methylation
- Demethylation
- Acetylation
- Phosphorylation
- Deacetylation
Research Areas
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM1A
bosterbio.com/bosterbio-gene-info-cards/KDM1A
References
PMID: 12032298 by Hakimi M.-A., et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.
PMID: 11102443 by Humphrey G.W., et al. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.