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- Table of Contents
Facts about Lysine-specific demethylase 5C.
Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
Human | |
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Gene Name: | KDM5C |
Uniprot: | P41229 |
Entrez: | 8242 |
Belongs to: |
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JARID1 histone demethylase family |
DXS1272EMRXJ; EC 1.14.11; EC 1.14.11.-; Histone demethylase JARID1C; JARID1Clysine-specific demethylase 5C; Jumonji, AT rich interactive domain 1C (RBP2-like); jumonji, AT rich interactive domain 1C; Jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; MRXSJ; Protein SmcX; Protein Xe169; Smcx homolog, X chromosome; SMCXselected cDNA on X; Smcy homolog, X-linked (mouse); Smcy homolog, X-linked; XE169JmjC domain-containing protein SMCX
Mass (kDA):
175.72 kDA
Human | |
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Location: | Xp11.22 |
Sequence: | X; NC_000023.11 (53176277..53225422, complement) |
Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.
Nucleus.
PMID: 8162017 by Wu J., et al. Isolation and characterization of XE169, a novel human gene that escapes X-inactivation.
PMID: 7951230 by Agulnik A.I., et al. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.