Lysine-specific demethylase 5C (KDM5C)

Histone demethylase that especially demethylates'Lys- 4' of histone H3, thereby playing a fundamental role in histone code (PubMed:28262558). Doesn't demethylate histone H3'Lys-9', H3'Lys-27', H3'Lys-36', H3'Lys-79' or' H4'Lys-20'.

Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.