KIDINS220 Antibodies

AND KIDINS220 ELISA kits, KIDINS220 Proteins

Many biological assays use antibodies to detect KIDINS220, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIDINS220 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIDINS220 antibodies...

We validate the specificity of these antibodies to KIDINS220 by testing them on tissues known to express KIDINS220 positively and negatively. Browse below to find the KIDINS220 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KIDINS220 Infographic by Boster Bio

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KIDINS220 (NM_020738) Human Over-expression Lysate

Human

$960
Cat # LS057498
20 µg, 100 µg

KIDINS220 Overview

Facts about Kinase D-interacting substrate of 220 kDa.

KIDINS220 3D structure. Source: alphafold

Kinase D-interacting substrate of 220 kDa (KIDINS220)

Promotes a protracted MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, leading to Rap1-dependent sustained ERK activation.

May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation.

Gene Information

Human
Gene Name:	KIDINS220
Uniprot:	Q9ULH0
Entrez:	57498

Family

Belongs to:

No superfamily

Alternative Names

kinase D-interacting substrate, 220kDa

Molecular Weight

Mass (kDA):
196.542 kDA

Genomic Context


Human

Location:	2p25.1
Sequence:	2; NC_000002.12 (8721081..8837613, complement)

Tissue Specificity

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Late endosome. Localized at late endosome before or after nerve growth factor (NGF) stimulation.

Diseases

Nervousness
Neoplasms
Inflammation
Melanoma
Asthma
Metastatic Melanoma
Bisphosphonate-associated Osteonecrosis
Neoplasm Metastasis
Cardiovascular Abnormalities
Brain Ischemia
Metastatic Malignant Neoplasm To The Lung
Tumor Progression
Neurodegenerative Disorders

Neoplasm Invasiveness
Ulcer
Immunologic Deficiency Syndromes
Malignant Neoplasms
Pheochromocytoma
Mammary Neoplasms
Acral Lentiginous Malignant Melanoma

Pathways

Transport
Localization
Rna Interference
Regulation Of Hormone Secretion
Axon Guidance
Hormone Secretion
Synaptic Transmission
Cell Death
Pathogenesis
Secretion
Synapse Maturation
Cell Migration
Proteolysis

Immune Response
Neurogenesis
Myelination
System Development
Cell Differentiation
Peptide Secretion
Regulation Of Synapse

PTMs

Phosphorylation
Cleavage

Biotinylation
Acetylation

Research Areas

Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIDINS220

References

PMID: 18089783 by Liao Y.-H., et al. ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma.

PMID: 27005418 by Josifova D.J., et al. Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.