Kelch-like protein 20 Antibodies

AND KLHL20 ELISA kits, Kelch-like protein 20 Proteins

Many biological assays use antibodies to detect Kelch-like protein 20, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 20 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 20 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 20 by testing them on tissues known to express KLHL20 positively and negatively. Browse below to find the KLHL20 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLHL20 Infographic by Boster Bio

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Anti-KLHL20 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A07519-1
100 μl/vial

KLHL20 Overview

Facts about Kelch-like protein 20.

KLHL20 3D structure. Source: alphafold

Kelch-like protein 20 (KLHL20)

The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, resulting in its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'- linked ubiquitination (PubMed:24768539).

Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also functions as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.

Gene Information

Human
Gene Name:	KLHL20
Uniprot:	Q9Y2M5
Entrez:	27252

Family

Belongs to:

No superfamily

Alternative Names

Kelch motif containing protein; kelch-like 20 (Drosophila); kelch-like ECT2 interacting protein; Kelch-like ECT2-interacting protein; kelch-like protein 20; Kelch-like protein X; KHLHX; KLEIPRP3-383J4.3; KLHLX

Molecular Weight

Mass (kDA):
67.955 kDA

Genomic Context


Human

Location:	1q25.1
Sequence:	1; NC_000001.11 (173714912..173786826)

Subcellular Localizations

Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite. Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280).

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Prostate
Hypoxia
Prostatic Neoplasms
Epithelial Metaplasia
Metaplasia
Tumor Progression
Von Hippel-lindau Syndrome
Corneal Neovascularization

Abrasion, Unspecified
Dystrophy
Tumor Angiogenesis
Hyperplasia
Pathologic Neovascularization

Interacting Proteins

CUL3
DAPK1
PML
PRMT6

Pathways

Cell Migration
Cell Death
Proteolysis
Angiogenesis
Autophagy

PTMs

Ubiquitination

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLHL20

References

PMID: 14668487 by Hara T., et al. Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells.

PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.