Histone-lysine N-methyltransferase 2A (KMT2A)

Histone methyltransferase that plays a vital role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of'Lys-4' of histone H3 (H3K4me) complex and acetylation of'Lys-16' of histone H4 (H4K16ac).

From the MLL1/MLL complex, it specifically mediates H3K4me, a particular tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to acquire whole methyltransferase activity (PubMed:19187761, PubMed:26886794).