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1 Citations 9 Q&As
Facts about Kininogen-1.
prostaglandins), (4F) it's a cardioprotective effect (directly through bradykinin action, indirectly via endothelium-derived relaxing factor activity ); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting. .
Human | |
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Gene Name: | KNG1 |
Uniprot: | P01042 |
Entrez: | 3827 |
Belongs to: |
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No superfamily |
Alpha-2-thiol proteinase inhibitor; BDK; bradykinin; Fitzgerald factor; High molecular weight kininogen; kininogen 1; kininogen; kininogen-1; KNGHMWK; Williams-Fitzgerald-Flaujeac factor
Mass (kDA):
71.957 kDA
Human | |
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Location: | 3q27.3 |
Sequence: | 3; NC_000003.12 (186717359..186744410) |
Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
Secreted, extracellular space.
This article introduces the Boster bio: The KNG1 marker and discusses the Methods and Results. This article will explain the background of Steven Boster and how he created this marker for cell culture research. Furthermore, you'll find out about its best uses in a variety animal studies. It's a must for any immunologist and biologist.
KNG1 is a cysteine protease inhibitor. It participates in various physiological functions, including blood coagulation, inflammation response, and apoptosis regulation. It has been shown to prevent metastasis from cancer cells. It has been identified as a potential prognostic sign in several types, including CRC or HCC.
This protein is present in almost all types of cancers. However the presence of this marker within a sample can help differentiate between two types. Peak 1944 was found in CRA–H, but it was lower in CRA–S. The expression was higher in CRAs than CRC patients, but lower in HCs. The expression of the protein decreased with increasing CRC cases. Western blot analysis confirmed KNG1 through the detection of its Da form.
CRC patients also had tissues containing the protein. This was consistent in previous studies which found decreased KNG1 levels both in serum and the urine. Its expression levels were also higher in the tumor tissues, suggesting that KNG1 is a promising target for cancer diagnosis. Researchers can then use this marker to detect the early stages of cancer. This could lead the development of new prevention and treatment methods.
Combining KNG1, APOC3 and PON1 was able to diagnose YDH syndrome with high sensitivity. Combining these three markers helped to improve negative predictive values as well as positively diagnose the disease. The study's results were also improved by using APOC3, KNG1, and PON1. This study has demonstrated that KNG1 can be used to diagnose YDH syndrome.
The KNG1 marker has been associated with cognitive function in patients with Parkinson's disease. In one study, increased KNG1 levels were associated with a lower RBANS (Relative Brain Activity Score) and MoCA (Memory Condition Assessment) total score. These associations were independent of disease duration, sex, and cognitive impairment. Hyposmia and anxiety are possible confounders.
The expression levels of KNG1 were similar in tissues of CRC and CRA and in healthy colon mucosa. These results suggest that KNG1 may be associated to polygenic susceptibility (DVT) Genetic analysis suggests a KNG1 deficit reduces the risk for thrombosis. It is not clear what molecular mechanism DVT works. Further research is needed to understand how KNG1 interacts DVTAOS.
The association with the DVTAOS (AEC2) protein determines the KNG1 gene's DVTAOS status. In addition, two SNPs, rs710446 at the KNG1 gene and rs2069588 in BDKRB2, were associated with DVTAOS. KNG1 gene is where KNG1 lies. This association was strongest. This study could have a greater impact than other studies on DVTAOS.
There were two other markers that showed a significant association with KNG1: HPA001645 and HPA001615. After these markers were added, the association between KNG1 and the CRC genes remained significant. These results indicate that HPA001645 can be used as a useful marker. This marker can be used for the identification of a gene associated with colon cancer. Further research is required to confirm the association between KNG1 & the CRC gene.
The high quality marker panel used in this study was enriched for the GAPDH gene. The protein expression was normalized with other internal reference genes such as Lamin B1. The KNG1 gene has been identified as a very specific gene in this study. These genes were also found within more than 50% of the samples. These results can be indicative of possible bias due the sampling. The KNG1 genetic marker is important in cancer research.
PMID: 6441591 by Ohkubo I., et al. Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen.
PMID: 2989293 by Takagaki Y., et al. Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.
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