LRTOMT Antibodies

AND LRTOMT ELISA kits, LRTOMT Proteins

Many biological assays use antibodies to detect LRTOMT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRTOMT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRTOMT antibodies...

We validate the specificity of these antibodies to LRTOMT by testing them on tissues known to express LRTOMT positively and negatively. Browse below to find the LRTOMT antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRTOMT Infographic by Boster Bio

All LRTOMT Products

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Anti-LRTOMT Antibody Picoband®

1 Q&As

Western blot analysis of LRTOMT using anti-LRTOMT antibody (A13092-1)

IHC analysis of LRTOMT using anti-LRTOMT antibody (A13092-1)

Human, Mouse, Rat

IHC, WB

$370
Cat # A13092-1
100 μg/vial

LRRC51 (NM_145309) Human Recombinant Protein

Coomassie blue staining of purified LRTOMT protein

$1249
Cat # PROTQ8WZ04
20 µg

LRTOMT Overview

Facts about Transmembrane O-methyltransferase.

LRTOMT 3D structure. Source: alphafold

Transmembrane O-methyltransferase (LRTOMT)

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526).

Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the meeting of the asymmetric tip-link MET complicated.

Gene Information

Human
Gene Name:	LRTOMT
Uniprot:	Q8WZ04
Entrez:	220074

Family

Belongs to:

class I-like SAM-binding methyltransferase superfamily

Alternative Names

leucine rich transmembrane and 0-methyltransferase domain containing; TOMT

Molecular Weight

Mass (kDA):
32.155 kDA

Genomic Context


Human

Location:	11q13.4
Sequence:	11; NC_000011.10 (72080342..72110782)

Subcellular Localizations

[Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Cytoplasm. Endoplasmic reticulum. Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia (PubMed:28504928). Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern (By similarity).

Diseases

Complete Hearing Loss
Deafness Congenital
Sensorineural Hearing Loss (disorder)
Deaf Mutism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRTOMT

References

PMID: 18953341 by Ahmed Z.M., et al. Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.

PMID: 18794526 by Du X., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans.