Macf1 Antibodies

AND Macf1 ELISA kits, Macf1 Proteins

Many biological assays use antibodies to detect Macf1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Macf1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Macf1 antibodies...

We validate the specificity of these antibodies to Macf1 by testing them on tissues known to express Macf1 positively and negatively. Browse below to find the Macf1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Macf1 Infographic by Boster Bio

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Anti-MACF1 Antibody

Human, Mouse

ELISA, IF, IHC, ICC, WB

$370
Cat # A03509
100 μl/vial

Macf1 Overview

Facts about Microtubule-actin cross-linking factor 1.

Microtubule-actin cross-linking factor 1 (Macf1)

Isoform 2: F-actin-binding protein that plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:16815997, PubMed:18854161, PubMed:21295697). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity).

Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (PubMed:16815997). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (PubMed:18854161).

Gene Information

Mouse
Gene Name:	Macf1
Uniprot:	Q9QXZ0
Entrez:	11426

Family

Belongs to:

plakin or cytolinker family

Alternative Names

microtubule-actin crosslinking factor 1

Molecular Weight

Mass (kDA):
831.878 kDA

Genomic Context


Mouse

Location:	4 D2.2\|4 57.42 cM
Sequence:	4;

Tissue Specificity

Enriched in the hair follicle stem cells (at protein level). Isoform 1 and isoform 2 are ubiquitous expressed, with higher levels seen in lung, heart, thymus, spleen and brain.

Diseases

Nervousness
Tissue Adhesions
Bullous Pemphigoid
Malignant Neoplasms
Neoplasms
Carcinoma
Mammary Neoplasms
Disease Due To Parvoviridae
Liver Carcinoma
Liver Neoplasms
Erythema Infectiosum
Parvovirus B19 (disease)
Dystonia Disorders

Nervous System Disorder
Autoimmune Reaction
Hepatitis B
Neoplasm Invasiveness
Unbalanced Translocation
Ectopic Tissue
Adenocarcinoma

Pathways

Localization
Cell Proliferation
Transport
Cell Migration
Cell Cycle
Wound Healing
Gastrulation
Pathogenesis
Cell Adhesion
Response To Wounding
Lung Development
Immune Response
Mesoderm Formation

Neurogenesis
Inner Ear Development
Axon Extension
Muscle Attachment
Translation
Cell Motility
Cell Differentiation

PTMs

Phosphorylation

Glycosylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Macf1

References

PMID: 10601340 by Leung C.L., et al. Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons.

PMID: 16076900 by Lin C.-M., et al. Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex.