MAP4K5 Antibodies

Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

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Gene Information

Human
Gene Name:	MAP4K5
Uniprot:	Q9Y4K4
Entrez:	11183

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; GCKR; germinal center kinase-related; KHS1; KHSMEKKK 5; Kinase homologous to SPS1/STE20; MAP4K5; MAPK/ERK kinase kinase kinase 5; MAPKKKK5; MEK kinase kinase 5; mitogen-activated protein kinase kinase kinase kinase 5

Molecular Weight

Mass (kDA):
95.024 kDA

Genomic Context

Human
Location:	14q22.1
Sequence:	14; NC_000014.9 (50418475..50561126, complement)

Tissue Specificity

Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.

Subcellular Localizations

Cytoplasm.

Diseases

• Cardiac Failure Chronic
• Adenocarcinoma
• Lung Neoplasms
• Non-small Cell Lung Carcinoma
• Heart Failure
• Colonic Neoplasms
• Diabetes Mellitus
• Cardiomyopathy, Dilated
• Growth Retardation
• Diabetes Mellitus, Non-insulin-dependent
• Patient Dependence On

• Malignant Neoplasms
• Oncolysis
• Obesity
• Neoplasms
• Pancreatic Neoplasm
• Malignant Neoplasm Of Pancreas

Interacting Proteins

• CRK
• GRB2
• NCK1

Pathways

• Clathrin-mediated Endocytosis
• Cell Cycle
• Insulin Secretion
• Endocytosis
• Secretion

PTMs

• Phosphorylation

• Ubiquitination

Research Areas

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP4K5

Best Uses Of The MAP4K5 Marker

If you are looking for a biological indicator, it may be useful to choose one that is specific for a particular protein, such the MAP4K5 protein. The MAP4K5 is present in many animal samples so antibodies that can detect it are a great choice for biological assays. Boster Bio has antibodies against the MAP4K5 protein specific for both mouse and rabbit.

Boster Bio's new MAP4K5 Marker

The MAP4K5 kinase marker can be detected by a variety of biological assays. It binds with MAP4K5 to activate other proteins, including ERK1 or JNK. MAP4K5 also interacts with MAPK13, MAP3 and MAPK14. Boster Bio's MAP4K5Marker uses rabbit and mouse for its antibodies.

Clinical applications

Recently, the MAP4K5 protein marker was identified for use in cancer research. This protein is found in many tissues, including the liver, pancreas, and kidneys. These markers can be used to guide treatment selection and determine treatment effectiveness. However, the performance metrics of these biomarkers can differ from disease to disease and among different populations. Performance metrics for a given biomarker may also depend upon the disease's prevalence, type of treatment and time taken to analyze it. Clinical applications of this marker must include the context of its downstream application in the discovery design process, and the validation cohort must confirm the clinical value.

In 1997, S. cerevisiae cells were used to isolate the MAP4K5 proteins. It shares 55% amino Acid identity with the MAP4K2 protein and has the N-terminal Catalytic Domain. The MAP4K5 gene was found in various tissues. It was then purified by immunoblot and SDS–PAGE. Additionally, the protein was also detected on several tissues.

The MAP4K5 Gene is one of several components of the MAP kinase Signal Cascades. It activates Jun kinase in mammalian Cells. This pathway is more active in type 2. The researchers genotyped 1,399 cases using the MAP4K5 -822G/A marker. The patients were also subgroup-divided based on waist circumference.

Pancreatic cancer risk is increased when MAP4K5 expression drops. Pancreatic cancer diagnosis may be made by MAP4K5 deficiency. Further research is needed to identify the molecular mechanisms involved in the loss of MAP4K5 expression. The risk of developing PDAC may also be reduced by this protein. This research could change the way we manage and diagnose cancer.

Molecular biology

MAP4K5 is a member the protein kinase families. It is present in all cell types. It is found in all cell types. It could be involved in the environmental stress response, which is a response that is triggered by changes in the surrounding environment. MAP4K5 codes for two proteins, one of which can be identical to the others.

MAP4K5 had been identified as a candidate genes for the CREB transcript factor CPEB. It has been suggested this gene contributes in short-term memory conversion from implicit to longer-term memory. CREB-1 is involved with the conversion of implicit memory to declarative memory. Long-term memories are affected by CPEB. Molecular biology and the MAP4K5 marker are closely related and share a similar role in synaptic plasticity.