Mitogen-activated protein kinase 11 (MAPK11)

Serine/threonine kinase which functions as an important part of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors.

Accordingly, p38 MAPKs phosphorylate a wide assortment of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14.