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MAPKBP1 Antibodies
AND MAPKBP1 ELISA kits, MAPKBP1 Proteins
Many biological assays use antibodies to detect MAPKBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPKBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPKBP1 antibodies...
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MAPKBP1 Infographic by Boster Bio
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MAPKBP1 Overview
Facts about Mitogen-activated protein kinase-binding protein 1.
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1)
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971).
Involved in JNK signaling pathway (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPKBP1 |
| Uniprot: | O60336 |
| Entrez: | 23005 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AOA1EAOH; AOAMGC1072; aprataxin; ataxia 1, early onset with hypoalbuminemia; AXA1; EC 3.-; EOAHA; FHA-HIT; FLJ20157; Forkhead-associated domain histidine triad-like protein
Molecular Weight
Mass (kDA):
163.818 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q15.1 |
| Sequence: | 15; NC_000015.10 (41774484..41827855) |
Tissue Specificity
Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes (PubMed:22700971). Expressed in kidney (PubMed:28089251).
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Catatonia
- Myocardial Reperfusion Injury
- Ischemia
- Diabetes Mellitus, Experimental
- Pituitary Diseases
Interacting Proteins
- GLRX3
- KEAP1
- KRT31
- KRT40
- KRTAP10-7
- KRTAP10-8
- KRTAP10-9
- KRTAP3-2
- KRTAP4-12
- KRTAP5-9
Pathways
- Cell Death
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPKBP1
bosterbio.com/bosterbio-gene-info-cards/MAPKBP1
References
PMID: 15491607 by Homma K., et al. Alternative splice variants encoding unstable protein domains exist in the human brain.
PMID: 22700971 by Lecat A., et al. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process.