MGST1 Antibodies

Microsomal glutathione S-transferase 1 (MGST1)

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a broad substrate specificity.

.

Gene Information

Human
Gene Name:	MGST1
Uniprot:	P10620
Entrez:	4257

Family

Belongs to:
MAPEG family

Alternative Names

glutathione S-transferase 12; GST12EC 2.5.1.18; MGC14525; MGST; MGST-I; microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I

Molecular Weight

Mass (kDA):
17.599 kDA

Genomic Context

Human
Location:	12p12.3
Sequence:	12; NC_000012.12 (16347142..16377192)

Tissue Specificity

Highly expressed in liver.

Subcellular Localizations

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

• Malignant Neoplasms
• Neoplasms
• Inflammation
• Malignant Neoplasm Of Lung
• Carcinogenesis
• Neoplasm Metastasis
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Inflammatory Response
• Age Related Macular Degeneration
• Lung Neoplasms
• Malignant Neoplasm Of Breast

• Ataxia
• Atrichia
• Glaucoma, Open-angle
• Hypoxia
• Infertility
• Sarcoma
• Dental Fluorosis, Acquired

Interacting Proteins

• NELFB

Pathways

• Conjugation
• Dna Repair
• Cell Death
• Aging
• Proteolysis
• Cell Cycle
• Drug Resistance
• Transport
• Response To Oxidative Stress
• Cell Growth
• Muscle Contraction
• Response To Paraquat
• Oxidative Phosphorylation

• Liver Development
• Cell Cycle Arrest
• Spermatogenesis
• Inflammatory Response
• Cell Division
• Drug Transport
• Gonad Development

PTMs

• Reduction
• Nitrosylation
• Nitration

• Phosphorylation
• Oxidation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MGST1

Best Uses Of The MGST1 Marker From Boster Bio

If you are looking for the best antibody for the MGST1 marker, you've come to the right place. Listed below are some of the best boster bio products to consider. They are designed to target multiple targets with high affinity and specificity. Boster also rewards the first reviewer of a product with a product credit. The company rewards scientists worldwide. If you're a scientist and you're looking for the best antibody for your experiments, read on to learn more.

MGST1

MGST1 is an important enzyme involved in redox-homeostatic mechanisms. Increased ROS lead to the oxidative stress-induced senescence of young mesangial cells. MGST1 downregulation is linked to aging and disease in various systems, including human and animal physiology. MiR-34a has also been linked to aging and disease, including cancer and chronic obstructive pulmonary disease. It also targets SIRT1/6, which plays a role in senescence and redox-homeostatic mechanisms in the redox-homeostatic systems.

PCBD1

The gene PCBD1 encodes a protein called pterin-4 alpha-carbinolamine dehydratase, which recycles a component of the cell called tetrahydrobiopterin. This compound plays an important role in the metabolism of amino acids, including phenylalanine, by converting it into tyrosine. This protein is also involved in neurotransmitters that send signals between nerve cells. It is important for protein building and is also involved in the process of detoxification.

HNF1a

MGST1 is a gene on chromosome 12 that encodes a protein that is involved in redox control and detoxification. In humans, it is essential for preventing hepatitis B virus infection. It also acts as a key regulator of the NF-kB signaling pathway. Its target is HBV, but other viruses such as HIV also infect the liver.

HNF1b

MGST1 is a gene that has a role in hematopoiesis. In mice, MGST1 was expressed at high levels, and knockdown by lentiviral shRNA dramatically reduced the number of differentiated hematopoietic cells. Knockdown of MGST1 decreased mitochondrial metabolism and induced the induction of glycolytic enzymes, which are intimately coupled with HSPC dynamics. This gene is essential for hematopoiesis and embryonic development in vertebrates, and is therefore crucial for hematopoietic stem cell differentiation.

This gene is expressed in almost all recognizable nuclei of the pancreas. It is expressed in pancreatic duct cells, and can be detected as early as E13.5. Hnf1b and MGST1 are inserted into the Cre recombinase gene through a process called transgenic expression. It has been shown that the CreER gene, which encodes MGST1, recapitulates the expression of Hnf1b.

A study performed on M-ADSCs found that these cells showed a reduction in discrete degree on induction day three, indicating synchronization. Transcriptomes were not significantly different on day nine compared to day thirteen, but several key genes related to liver specialization were upregulated. HNF1b, MGST1 marker and AFP were detected in 92.1% and 93.3% of induced cells, respectively, and at day 13 these cells reached a peak of 99.8% and 99.9%, respectively.