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MOCS3 Antibodies
AND MOCS3 ELISA kits, MOCS3 Proteins
Many biological assays use antibodies to detect MOCS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MOCS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MOCS3 antibodies...
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MOCS3 Overview
Facts about Adenylyltransferase and sulfurtransferase MOCS3.
Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3)
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor.
Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first interrupts URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is moved to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.
Gene Information
| Human | |
|---|---|
| Gene Name: | MOCS3 |
| Uniprot: | O95396 |
| Entrez: | 27304 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
adenylyltransferase and sulfurtransferase MOCS3; dJ914P20.3; molybdenum cofactor synthesis 3; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; MPT synthase sulfurylase; UBA4, ubiquitin-activating enzyme E1 homolog; UBA4MGC9252; ubiquitin-like modifier activating enzyme 4
Molecular Weight
Mass (kDA):
49.669 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.13 |
| Sequence: | 20; NC_000020.11 (50958818..50963929) |
Subcellular Localizations
Cytoplasm.
Diseases
- Combined Molybdoflavoprotein Enzyme Deficiency
- Trauma, Nervous System
- Sulfocysteinuria
- Duane Retraction Syndrome
- Charge Syndrome
- Brain Ischemia
- Atresia
- Inborn Errors Of Metabolism
- Neurodegenerative Disorders
- Developmental Delay (disorder)
- Hypoxia
- Developmental Disabilities
Interacting Proteins
- URM1
Pathways
- Conjugation
- Protein Urmylation
- Translation
- Trna Modification
- Cellular Localization
- Localization
PTMs
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MOCS3
bosterbio.com/bosterbio-gene-info-cards/MOCS3
References
PMID: 15073332 by Matthies A., et al. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.
PMID: 15910006 by Matthies A., et al. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.