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- Table of Contents
Facts about Adenylyltransferase and sulfurtransferase MOCS3.
Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first interrupts URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is moved to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.
Human | |
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Gene Name: | MOCS3 |
Uniprot: | O95396 |
Entrez: | 27304 |
Belongs to: |
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No superfamily |
adenylyltransferase and sulfurtransferase MOCS3; dJ914P20.3; molybdenum cofactor synthesis 3; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; MPT synthase sulfurylase; UBA4, ubiquitin-activating enzyme E1 homolog; UBA4MGC9252; ubiquitin-like modifier activating enzyme 4
Mass (kDA):
49.669 kDA
Human | |
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Location: | 20q13.13 |
Sequence: | 20; NC_000020.11 (50958818..50963929) |
Cytoplasm.
PMID: 15073332 by Matthies A., et al. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.
PMID: 15910006 by Matthies A., et al. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.