Helicase MOV-10 (MOV10)

5' to 3' RNA helicase leading to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).

In collaboration with FMR1, regulates miRNA- mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE- 1) in collaboration with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).