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- Table of Contents
Helicase MOV-10 Antibodies
AND MOV10 ELISA kits, Helicase MOV-10 Proteins
Many biological assays use antibodies to detect Helicase MOV-10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Helicase MOV-10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Helicase MOV-10 antibodies...
Designing a Western blot for Helicase MOV-10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MOV10 Western Blot GuideMOV10 Infographic by Boster Bio
All MOV10 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04952
100 μg/vial
Cat # A04952
100 μg/vial
MOV10 Overview
Facts about Helicase MOV-10.
Helicase MOV-10 (MOV10)
5' to 3' RNA helicase leading to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).
In collaboration with FMR1, regulates miRNA- mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE- 1) in collaboration with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).
Gene Information
| Human | |
|---|---|
| Gene Name: | MOV10 |
| Uniprot: | Q9HCE1 |
| Entrez: | 4343 |
Family
| Belongs to: |
|---|
| DNA2/NAM7 helicase family |
Alternative Names
DKFZp667O1423; EC 3.6.1; EC 3.6.4.13; FLJ32791; KIAA1631mouse) homolog; Mov10, Moloney leukemia virus 10, homolog (mouse)
Molecular Weight
Mass (kDA):
113.671 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.2 |
| Sequence: | 1; NC_000001.11 (112674312..112702377) |
Subcellular Localizations
Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Nucleus. Cytoplasm. Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).
Diseases
- Hiv Infections
- Leukemia
- Immunologic Deficiency Syndromes
- Retroviridae Infections
- Hepatitis
- Chikungunya Virus Infection
- Embryonal Carcinoma
- Infertility
- Patient Dependence On
- Malignant Neoplasms
- Neoplasms
- Encephalitis
Interacting Proteins
- BMI1
- CBX6
- CBX7
- Cbx7
- CBX8
- EIF2AK2
- PCGF2
Pathways
- Translation
- Gene Silencing
- Localization
- Reverse Transcription
- Rna Processing
- Rna Interference
- Transport
- Cell Proliferation
- Brain Development
- Mrna Transport
- Chromosome Segregation
- Mrna Cleavage
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MOV10
bosterbio.com/bosterbio-gene-info-cards/MOV10
References
PMID: 16289642 by Meister G., et al. Identification of novel argonaute-associated proteins.
PMID: 17507929 by Chendrimada T.P., et al. MicroRNA silencing through RISC recruitment of eIF6.