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- Table of Contents
MTAP Antibodies
AND MTAP ELISA kits, MTAP Proteins
Many biological assays use antibodies to detect MTAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTAP antibodies...
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MTAP Infographic by Boster Bio
All MTAP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M05448
100 μl/vial
Cat # M05448
100 μl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A05448-2
100 µg/vial
Cat # A05448-2
100 µg/vial
MTAP Overview
Facts about S-methyl-5'-thioadenosine phosphorylase.
S-methyl-5'-thioadenosine phosphorylase (MTAP)
Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a significant by-product of polyamine biosynthesis.
Responsible for the initial step in the methionine salvage pathway after MTA was generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates.
Gene Information
| Human | |
|---|---|
| Gene Name: | MTAP |
| Uniprot: | Q13126 |
| Entrez: | 4507 |
Family
| Belongs to: |
|---|
| PNP/MTAP phosphorylase family |
Alternative Names
5'-methylthioadenosine phosphorylase; BDMF; C86fus; DMSFH; DMSMFH; EC 2.4.2.28; HEL-249; LGMBF; methylthioadenosine phosphorylase; MSAPMeSAdo phosphorylase; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase
Molecular Weight
Mass (kDA):
31.236 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.3 |
| Sequence: | 9; NC_000009.12 (21802636..21867081) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Leukemia
- Carcinoma
- Melanoma
- Acute Lymphocytic Leukemia
- Malignant Neoplasm Of Lung
- Skin Neoplasms
- Cell Transformation, Neoplastic
- Glioma
- Lymphoma
- Adult T-cell Lymphoma/leukemia
Interacting Proteins
- CENPH
Pathways
- Methylation
- Pathogenesis
- Cell Growth
- Quorum Sensing
- Cell Cycle
- Interphase
- Dna Methylation
- Localization
- Cell Death
- Pigmentation
- Oncogenesis
- Rna Interference
- Aging
PTMs
- Methylation
- Cleavage
- Demethylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTAP
bosterbio.com/bosterbio-gene-info-cards/MTAP
References
PMID: 7604019 by Olopade O.I., et al. Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.
PMID: 8650244 by Nobori T., et al. Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.