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Unconventional myosin-VI Antibodies
AND MYO6 ELISA kits, Unconventional myosin-VI Proteins
Many biological assays use antibodies to detect Unconventional myosin-VI, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Unconventional myosin-VI in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Unconventional myosin-VI antibodies...
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MYO6 Overview
Facts about Unconventional myosin-VI.
Unconventional myosin-VI (MYO6)
Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments.
Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in many different intracellular processes like vesicular membrane trafficking and cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYO6 |
| Uniprot: | Q9UM54 |
| Entrez: | 4646 |
Family
| Belongs to: |
|---|
| TRAFAC class myosin-kinesin ATPase superfamily |
Alternative Names
DFNA22; DFNB37; KIAA0389deafness, autosomal recessive 37; myosin VI; myosin-VI; Unconventional myosin-6
Molecular Weight
Mass (kDA):
149.691 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q14.1 |
| Sequence: | 6; NC_000006.12 (75749203..75919537) |
Tissue Specificity
Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.
Subcellular Localizations
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus. Nucleus. Cytoplasm, perinuclear region. Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Cell projection, filopodium. Cell projection, ruffle membrane. Cell projection, microvillus. Cytoplasm, cytosol. Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffl
Diseases
- Complete Hearing Loss
- Sensorineural Hearing Loss (disorder)
- Carcinoma
- Malignant Neoplasms
- Prostatic Neoplasms
- Deafness Congenital
- Malignant Neoplasm Of Prostate
- Fibrosis
- Malignant Paraganglionic Neoplasm
- Circling Gait
- Post-traumatic Stress Disorder
- Usher Syndrome
Interacting Proteins
- DAB2
- Dab2
- Gipc1
Pathways
- Endocytosis
- Transport
- Clathrin-mediated Endocytosis
- Localization
- Secretion
- Synapse Maturation
- Golgi Localization
- Anion Transport
- Ion Transport
- Neurogenesis
- Synaptic Transmission
- Inner Ear Development
- Organ Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYO6
bosterbio.com/bosterbio-gene-info-cards/MYO6
References
PMID: 9259267 by Avraham K.B., et al. Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice.
PMID: 16344560 by Kimura K., et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.