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Neurochondrin Antibodies
AND NCDN ELISA kits, Neurochondrin Proteins
Many biological assays use antibodies to detect Neurochondrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Neurochondrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Neurochondrin antibodies...
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NCDN Infographic by Boster Bio
All NCDN Products
Product
Figures
Specificity
Applications
Price
Human
$960
Cat # LS023154
20 µg, 100 µg
Cat # LS023154
20 µg, 100 µg
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A10337-2
100 μg/vial
Cat # A10337-2
100 μg/vial
NCDN Overview
Facts about Neurochondrin.
Neurochondrin (NCDN)
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process.
Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCDN |
| Uniprot: | Q9UBB6 |
| Entrez: | 23154 |
Family
| Belongs to: |
|---|
| neurochondrin family |
Alternative Names
KIAA0607NCDN-1; NCDN-2; neurochondrin
Molecular Weight
Mass (kDA):
78.864 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.3 |
| Sequence: | 1; NC_000001.11 (35557792..35566779) |
Tissue Specificity
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
Subcellular Localizations
Cytoplasm, cytosol. Cell projection, dendrite. Localizes to somatic regions of neurons.
Diseases
- Pain
- Hyperlipidemia
- Impaired Cognition
- Tissue Adhesions
- Intervertebral Disc Degeneration
- Back Pain
Interacting Proteins
- AES
- EFHC2
- TINF2
Pathways
- Cell Adhesion
- Regeneration
- Reverse Transcription
- Cell Differentiation
- Aging
- Neurogenesis
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCDN
bosterbio.com/bosterbio-gene-info-cards/NCDN
References
PMID: 10524216 by Mochizuki R., et al. Molecular cloning and expression of human neurochondrin-1 and -2.
PMID: 16945926 by Francke F., et al. Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.