NEK4 Antibodies

AND NEK4 ELISA kits, NEK4 Proteins

Many biological assays use antibodies to detect NEK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEK4 antibodies...

We validate the specificity of these antibodies to NEK4 by testing them on tissues known to express NEK4 positively and negatively. Browse below to find the NEK4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEK4 Infographic by Boster Bio

All NEK4 Products

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Anti-Nek4 Antibody

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A09128
100ul

NEK4 Overview

Facts about Serine/threonine-protein kinase Nek4.

NEK4 3D structure. Source: alphafold

Serine/threonine-protein kinase Nek4 (NEK4)

Protein kinase which appears to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest following a limited number of cell divisions, also called replicative senescence.

Required for normal cell cycle arrest in response to double-stranded DNA damage. .

Gene Information

Human
Gene Name:	NEK4
Uniprot:	P51957
Entrez:	6787

Family

Belongs to:

protein kinase superfamily

Alternative Names

Serine/threonine-protein kinase Nek4

Molecular Weight

Mass (kDA):
94.597 kDA

Genomic Context


Human

Location:	3p21.1
Sequence:	3; NC_000003.12 (52708444..52770949, complement)

Tissue Specificity

Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.

Subcellular Localizations

Cell projection, cilium. Cytoplasm.

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEK4

References

PMID: 8208544 by Levedakou E.N., et al. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.

PMID: 21685204 by Coene K.L., et al. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.