Ribosome biogenesis protein NOP53 (NOP53)

Nucleolar protein that's involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611).

Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in reaction to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis interrupt the interaction between NOP53 and RPL11 allowing RPL11 transfer to the nucleoplasm where it can inhibit MDM2 and permit p53/TP53 activation (PubMed:24120868, PubMed:27829214).