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Facts about Ribosome biogenesis protein NOP53.
Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in reaction to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis interrupt the interaction between NOP53 and RPL11 allowing RPL11 transfer to the nucleoplasm where it can inhibit MDM2 and permit p53/TP53 activation (PubMed:24120868, PubMed:27829214).
Human | |
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Gene Name: | NOP53 |
Uniprot: | Q9NZM5 |
Entrez: | 29997 |
Belongs to: |
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NOP53 family |
Ribosome biogenesis protein NOP53
Mass (kDA):
54.389 kDA
Human | |
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Location: | 19q13.33 |
Sequence: | 19; NC_000019.10 (47745546..47757058) |
Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.
Nucleus, nucleolus. Nucleus, nucleoplasm. In the nucleolus may be more specifically localized to the fibrillar center (PubMed:27729611). Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53 (PubMed:22522597, PubMed:24923447, PubMed:27323397, PubMed:26903295). Also detected in the cytosol (PubMed:24923447, PubMed:27824081).
PMID: 10708517 by Smith J.S., et al. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region.
PMID: 10196275 by Bruni R., et al. A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type- specific manner and is recruited to the nucleus after infection.