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- Table of Contents
NOTCH3 Antibodies
AND NOTCH3 ELISA kits, NOTCH3 Proteins
Many biological assays use antibodies to detect NOTCH3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH3 antibodies...
Designing a Western blot for NOTCH3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NOTCH3 Western Blot GuideNOTCH3 Infographic by Boster Bio
All NOTCH3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00485-1
100 μg
Cat # M00485-1
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00485
100 μg
Cat # M00485
100 μg
NOTCH3 Overview
Facts about Neurogenic locus notch homolog protein 3.
Neurogenic locus notch homolog protein 3 (NOTCH3)
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | NOTCH3 |
| Uniprot: | Q9UM47 |
| Entrez: | 4854 |
Family
| Belongs to: |
|---|
| NOTCH family |
Alternative Names
CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3
Molecular Weight
Mass (kDA):
243.631 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (15159038..15200995, complement) |
Tissue Specificity
Ubiquitously expressed in fetal and adult tissues.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
Diseases
- Cadasil Syndrome
- Arteriopathic Disease
- Leukoencephalopathies
- Cerebrovascular Accident
- Dementia
- Migraine Disorders
- Neoplasms
- Malignant Neoplasms
- Multi-infarct Dementia
- Dementia, Vascular
- Impaired Cognition
- Carcinoma
- Vascular Diseases
Interacting Proteins
- Psma1
Pathways
- Pathogenesis
- Notch Signaling Pathway
- Cell Differentiation
- Cell Proliferation
- Angiogenesis
- Cell Cycle
- Cell Growth
- Regeneration
- Cell Death
- Neurogenesis
- Cell Development
- Cell Fate Specification
- Rna Interference
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Ubiquitination
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH3
bosterbio.com/bosterbio-gene-info-cards/NOTCH3
References
PMID: 8878478 by Joutel A., et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.
PMID: 10079256 by Gray G.E., et al. Human ligands of the Notch receptor.