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- Table of Contents
NPC1 Antibodies
AND NPC1 ELISA kits, NPC1 Proteins
Many biological assays use antibodies to detect NPC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPC1 antibodies...
Designing a Western blot for NPC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NPC1 Western Blot GuideDesigning an IHC experiment for NPC1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NPC1 IHC GuideNPC1 Infographic by Boster Bio
All NPC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A00428-3
100 μg/vial
Cat # A00428-3
100 μg/vial
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00428-2
100 μg/vial
Cat # A00428-2
100 μg/vial
Anti-Niemann Pick C1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00428-1
100 μl/vial
Cat # M00428-1
100 μl/vial
NPC1 Overview
Facts about NPC intracellular cholesterol transporter 1.
NPC intracellular cholesterol transporter 1 (NPC1)
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol in the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is moved by NPC2 into the cholesterol- binding pocket at the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760).
Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with greater affinity than cholesterol.
Gene Information
| Human | |
|---|---|
| Gene Name: | NPC1 |
| Uniprot: | O15118 |
| Entrez: | 4864 |
Family
| Belongs to: |
|---|
| patched family |
Alternative Names
FLJ98532; Niemann-Pick C1 protein; Niemann-Pick disease, type C1; Niemann-Pick Type C1; NPC; NPC1; SLC65A1
Molecular Weight
Mass (kDA):
142.167 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (23506184..23586506, complement) |
Subcellular Localizations
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Diseases
- Niemann-pick Diseases
- Niemann-pick Disease, Type C
- Nerve Degeneration
- Neurodegenerative Disorders
- Nervousness
- Storage Disease
- Lipoidosis
- Alzheimer's Disease
- Lysosomal Storage Diseases
- Nervous System Disorder
- Ataxia
- Neuropathology Disease
Interacting Proteins
- CAV1
Pathways
- Transport
- Cholesterol Transport
- Cholesterol Homeostasis
- Lipid Storage
- Localization
- Pathogenesis
- Cholesterol Efflux
- Cell Death
- Lipid Transport
- Cholesterol Storage
- Endocytosis
- Cholesterol Esterification
- Intracellular Cholesterol Transport
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Oxidation
- Acetylation
Research Areas
- Cancer
- Cholesterol Metabolism
- Lipid and Metabolism
- Membrane Trafficking and Chaperones
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPC1
bosterbio.com/bosterbio-gene-info-cards/NPC1
References
PMID: 9211849 by Carstea E.D., et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
PMID: 10425213 by Morris J.A., et al. The genomic organization and polymorphism analysis of the human Niemann-Pick C1 gene.