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We validate the specificity of these antibodies to NPC1L1 by testing them on tissues known to express NPC1L1 positively and negatively. Browse below to find the NPC1L1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about NPC1-like intracellular cholesterol transporter 1.
Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects.
Niemann-Pick C1-like protein 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC11L1
|Sequence:||7; NC_000007.14 (44512440..44541651, complement)|
Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
The NPC1L1 phylogenetic marker is one of the primary antibodies offered by Boster Bio. Researchers trust Boster's antibodies, which include the L1 element. Read on to learn more about how this marker works in phylogenetic analyses. You'll also discover how you can use this marker for further research. After all, phylogenetic analysis is the ultimate goal of a biological study.
Known for producing high-affinity, specific antibodies, Boster provides reliable products for the research community. The company's primary antibodies are tested on several matrices to ensure optimal performance. Many of these antibodies have received high citations in the research community, and the company stands behind its products. Furthermore, it offers detection kits for WB and IHC applications. The company manufactures its primary antibodies in-house and adheres to rigorous quality control standards to ensure the highest quality products.
With over 16,000 high-quality antibodies, Boster Bio provides excellent performance in multiple applications. The company offers primary antibodies and ELISA kits with rigorous validation. The company offers rabbit polyclonal antibodies and has a free secondary antibody with every purchase. Moreover, its comprehensive line of antibodies is optimized for ELISA and WB applications and are used for neuroscience research. Moreover, all products in the Boster Bio laboratory carry the company's Boster Quality Guarantee, which guarantees that the antibodies will perform as advertised.
Rockland produces a diverse range of monoclonal and polyclonal antibodies suitable for Western Blotting. These antibodies have high affinity and specificity for immunoblotting, flow cytometry, and immunohistochemistry. Most of the antibodies in Rockland's range are suitable for most immunological methods. Because of their high titer and specificity, these antibodies can also be used for ELISA and Western blotting.
When testing the quality of a primary antibody, it is vital to carefully control its purity. The primary antibody can only be tested if it is pure. Therefore, it is important to use a purified primary antibody with proper conditions of fixation and antigen-free antigen. The quality of a primary antibody is highly dependent on the source and the purity of the sample used. If the antigen is not expressed, there can be no effective primary antibody.
These retrotransposons comprise 17% of the human genome. Several of them are capable of retrotransposition and are believed to have evolved during the early eukaryotic stages. Their history suggests that they integrate into DNA through target primed reverse transcription. Their use in phylogenetic inference has been demonstrated using data from newly-identified proteobacteria genomes. These elements have been implicated in shaping mammalian genomes through multiple mechanisms. They also provide the machinery for retrotransposition of other mobile elements and shuffle non-L1 sequence throughout the genome by a process known as transduction.
Using the newly recovered genomes of uncultivated microorganisms, researchers can infer phylogenetic trees using the data. While the 16S ribosomal RNA small subunit genes have been established as the "gold standard" for phylogenetic inference, they have been inefficient in assembling metagenomes because of their shared regions. The use of single-copy marker genes for uncultivated species is gaining in popularity as an alternative for phylogenetic inference. Meanwhile, existing predefined marker gene sets for cultivated species have been applied to a variety of genomic studies. However, these may not be appropriate for novel or draft genomes.