Oxysterols receptor LXR-beta (NR1H2)

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats with the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).

Regulates cholesterol uptake through MYLIP- dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).