This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Oxysterols receptor LXR-beta.
Regulates cholesterol uptake through MYLIP- dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Human | |
---|---|
Gene Name: | NR1H2 |
Uniprot: | P55055 |
Entrez: | 7376 |
Belongs to: |
---|
nuclear hormone receptor family |
Liver X receptor beta; LXR beta; LXR-b; NER-I; NERliver X receptor-beta; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptorLXRB; UNR; UNRLX receptor beta
Mass (kDA):
50.974 kDA
Human | |
---|---|
Location: | 19q13.33 |
Sequence: | 19; NC_000019.10 (50376457..50383388) |
Ubiquitous.
Nucleus.
If you are in the market for an anti-NR1H2 antibody, you will be interested in Boster Bio's Anti-LXR beta/NER/NR1H2 antibody. This article will discuss its applications, validation, and pricing. You can also find out if Boster has published a validation protocol for the antibody. Boster Bio's Anti-LXR beta/NER/NR1H2 antibody has been used to analyze the function of the NR1H2 protein in a variety of biological assays.
This antibody recognizes a synthetic peptide from the human NR1H2 protein. This antibody can be used for immunohistochemistry of human tissue after heat-induced antigen retrieval. In addition to immunohistochemistry, this antibody is also suitable for use in chemiluminescence assays. Hence, it is a versatile tool for detecting the expression of NR1H2 and its related proteins.
The anti-LXR beta/NER/NR1/H2 antibody targets liver X receptors, which regulate cholesterol, bile acid, and fatty acid metabolism. The enzyme LPCAT3 mediates the interactions between oxysterols and lipids and regulates cholesterol transport into cellular membranes. Furthermore, it promotes phospholipid remodeling in ER membranes.
The cholesterol receptor protein is an essential protein for intracellular cholesterol homeostasis. It regulates the transport of lipid cholesterol between membranes and mediates the plasmatic response to dietary cholesterol. It also catalyzes the first reaction in catabolism and is a vital regulator in the synthesis of bile salts in the liver. In addition, this protein is involved in lipid synthesis.
The NR1H2 marker is an RNAi-based gene knockdown method. It knocks down the NR1H2 gene in a variety of host cell types. These tools are meant for research purposes and not for therapeutic or diagnostic use. Currently, there are no therapeutic uses for this siRNA. However, the NR1H2 siRNA is available in lentivirus, AAV and oligo formats.
Liver X receptor beta (LXR) or NR1H2 is a member of the NR1 receptor family. These receptors bind oxysterols and play key roles in cholesterol homeostasis. They regulate multiple components of reverse cholesterol transport and are potent inhibitors of inflammation. LXR-b is expressed more abundantly than LXR-a. The LXR-b antibody recognizes liver cells expressing both alpha and beta LXR-b.
Using six tagging SNPs, the NR1H2 gene variants were associated with elevated risk for type 2 diabetes in a European population. The variant was found to be significantly associated with AUC of insulin during the IVGTT and conferred reduced pancreatic b-cell function. The researchers believe that this variant may facilitate the onset of type 2 diabetes. They are currently testing patients for NR1H2 genetic variants.
PMID: 7926814 by Shinar D.M., et al. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
PMID: 20159957 by Venteclef N., et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.