NSD2 Antibodies

AND NSD2 ELISA kits, NSD2 Proteins

Many biological assays use antibodies to detect NSD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NSD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NSD2 antibodies...

We validate the specificity of these antibodies to NSD2 by testing them on tissues known to express NSD2 positively and negatively. Browse below to find the NSD2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NSD2 Infographic by Boster Bio

All NSD2 Products

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Figures

Specificity

Applications

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Anti-WHSC1 NSD2 Antibody

Western blot analysis of extracts of various cell lines, using WHSC1 antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded mouse lung using WHSC1 antibody at dilution of 1:100

Immunohistochemistry of paraffin-embedded mouse kidney using WHSC1 antibody at dilution of 1:100

Human, Mouse

IHC, WB

$405
Cat # A32441
100ul

Anti-WHSC1/NSD2 Antibody Picoband®

Western blot analysis of WHSC1/NSD2 using anti-WHSC1/NSD2 antibody (A32441-1)

Human, Monkey

ELISA, WB

$370
Cat # A32441-1
100 μg/vial

WHSC1 (NM_133330) Human Over-expression Lysate

WHSC1 Human Over-expression Lysates NM_133330

Human

$960
Cat # LS007468
20 µg, 100 µg

NSD2 Overview

Facts about Histone-lysine N-methyltransferase NSD2.

NSD2 3D structure. Source: alphafold

Histone-lysine N-methyltransferase NSD2 (NSD2)

Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.

Gene Information

Human
Gene Name:	NSD2
Uniprot:	O96028
Entrez:	7468

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

EC 2.1.1.43; FLJ23286; IL5 promoter REII region-binding protein; KIAA1090; MGC176638; MMSETNSD2Multiple myeloma SET domain-containing protein; multiple myeloma SET domain containing protein type III; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; Wolf-Hirschhorn syndrome candidate 1 protein; Wolf-Hirschhorn syndrome candidate 1

Molecular Weight

Mass (kDA):
152.258 kDA

Genomic Context


Human

Location:	4p16.3
Sequence:	4; NC_000004.12 (1871393..1982207)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Chromosome.; [Isoform 4]: Cytoplasm.

Diseases

Multiple Myeloma
Wolf-hirschhorn Syndrome
Malignant Neoplasms
Neoplasms
Chromosomal Translocation
Leukemia
Tissue Adhesions
Carcinogenesis
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Congenital Abnormality

Haploinsufficiency
Leukemia, Plasma Cell
Craniofacial Abnormalities
Malignant Neoplasm Of Lung
Cytogenetic Abnormality

Interacting Proteins

AR
MDC1

Pathways

Methylation
Pathogenesis
Cell Growth
Cell Cycle
Histone Methylation
Cell Adhesion
Cell Proliferation
Histone Acetylation
Rna Interference
Chromatin Remodeling
Regulation Of Cell Cycle
Localization
Epithelial To Mesenchymal Transition

Demethylation
Reverse Transcription
Mrna Splicing
Translation
S Phase
Histone H3-k27 Methylation
Chromatin Organization

PTMs

Methylation
Acetylation

Phosphorylation
Demethylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NSD2

References

PMID: 9787135 by Chesi M., et al. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.

PMID: 9618163 by Stec I., et al. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.