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Beta-parvin Antibodies
AND PARVB ELISA kits, Beta-parvin Proteins
Many biological assays use antibodies to detect Beta-parvin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-parvin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-parvin antibodies...
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PARVB Infographic by Boster Bio
All PARVB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M04707
100 µl
Cat # M04707
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M04707-1
100 µl
Cat # M04707-1
100 µl
PARVB Overview
Facts about Beta-parvin.
Beta-parvin (PARVB)
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia.
Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PARVB |
| Uniprot: | Q9HBI1 |
| Entrez: | 29780 |
Family
| Belongs to: |
|---|
| parvin family |
Alternative Names
affixin; beta-parvin; CGI-56; parvin, beta
Molecular Weight
Mass (kDA):
41.714 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.31 |
| Sequence: | 22; NC_000022.11 (43999164..44172939) |
Tissue Specificity
Expressed predominantly in heart and skeletal muscle.
Subcellular Localizations
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Tumor Angiogenesis
- Mammary Neoplasms
- Bulla
- Cell Invasion
- Muscular Dystrophy
- Diabetic Nephropathy
- Weakness
- Malignant Tumor Of Colon
Interacting Proteins
- Arhgef6
- Arhgef7
Pathways
- Cell Adhesion
- Cell Migration
- Cell Growth
- Cell Proliferation
- Localization
- Cell-matrix Adhesion
- Cell-substrate Adhesion
- Angiogenesis
- Regulation Of Cell Adhesion
- Cellular Senescence
- Dna Methylation
- Cellular Process
- Platelet Aggregation
PTMs
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARVB
bosterbio.com/bosterbio-gene-info-cards/PARVB
References
PMID: 11402068 by Yamaji S., et al. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.
PMID: 11171322 by Olski T.M., et al. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily.