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PDE10A Antibodies
AND PDE10A ELISA kits, PDE10A Proteins
Many biological assays use antibodies to detect PDE10A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE10A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE10A antibodies...
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PDE10A Infographic by Boster Bio
All PDE10A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M02605
100 µl
Cat # M02605
100 µl
Human, Mouse, Rat
Flow Cytometry, IF
$523
Cat # M02605-1
100 µl
Cat # M02605-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M02605-2
100 μl/vial
Cat # M02605-2
100 μl/vial
PDE10A Overview
Facts about cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE10A |
| Uniprot: | Q9Y233 |
| Entrez: | 10846 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
cAMP and cAMP-inhibited cGMP 3'-5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); EC 3.1.4; EC 3.1.4.17; EC 3.1.4.35; FLJ11894; FLJ25677; HSPDE10A; phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1)
Molecular Weight
Mass (kDA):
88.412 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q27 |
| Sequence: | 6; NC_000006.12 (165327287..165988115, complement) |
Tissue Specificity
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Subcellular Localizations
Cytoplasm. Located mostly to soluble cellular fractions.
Diseases
- Schizophrenia
- Mental Disorders
- Huntington Disease
- Psychotic Disorders
- Pcp - Hallucinogen-related Disorder
- Anxiety Disorders
- Globus Hystericus
- Impaired Cognition
- Bipolar Disorder
- Nervousness
- Hypokinesia
- Neurobehavioral Manifestations
- Impairment (finding)
Pathways
- Localization
- Cognition
- Secretion
- Insulin Secretion
- Transport
- Prepulse Inhibition
- Locomotion
- Cell Adhesion
- Proteolysis
- Lung Development
- Hypersensitivity
- Cardiac Conduction
- Reflex
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE10A
bosterbio.com/bosterbio-gene-info-cards/PDE10A
References
PMID: 10441464 by Kotera J., et al. Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.
PMID: 10373451 by Fujishige K., et al. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).