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PDE6D Antibodies
AND PDE6D ELISA kits, PDE6D Proteins
Many biological assays use antibodies to detect PDE6D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE6D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE6D antibodies...
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PDE6D Overview
Facts about Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)
Promotes the launch of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361).
Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE6D |
| Uniprot: | O43924 |
| Entrez: | 5147 |
Family
| Belongs to: |
|---|
| PDE6D/unc-119 family |
Alternative Names
GMP-PDE delta; PDED; phosphodiesterase 6D, cGMP-specific, rod, delta; Protein p17; retinal rod rhodopsin-sensitive cGMP 3'-5'-cyclic phosphodiesterase subunitdelta
Molecular Weight
Mass (kDA):
17.42 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (231732425..231781327, complement) |
Tissue Specificity
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
Diseases
- Retinitis Pigmentosa
- Retinal Degeneration
- Atrophic Retina
- Dog Diseases
- Atrophy
- Dysplasia
- Retinal Diseases
- Dystrophy
- Microphthalmos
- Familial Aplasia Of The Vermis
- Lung Diseases
Interacting Proteins
- ARL16
- ARL2
- Arl2
- ARL3
- Arl3
- RAB13
- RHEB
- RPGR
Pathways
- Transport
- Phototransduction
- Localization
- Lipid Binding
- Prenylation
- Protein Transport
PTMs
- Prenylation
- Farnesylation
Research Areas
- Signal Transduction
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE6D
bosterbio.com/bosterbio-gene-info-cards/PDE6D
References
PMID: 9570951 by Li N., et al. Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene.
PMID: 9533031 by Erchova G., et al. cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36.