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- Table of Contents
PDK3 Antibodies
AND PDK3 ELISA kits, PDK3 Proteins
Many biological assays use antibodies to detect PDK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDK3 antibodies...
Designing a Western blot for PDK3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDK3 Western Blot GuideDesigning an IHC experiment for PDK3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PDK3 IHC GuidePDK3 Infographic by Boster Bio
All PDK3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05658-1
100 µg/vial
Cat # A05658-1
100 µg/vial
PDK3 Overview
Facts about [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3)
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2.
Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient amounts and under starvation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDK3 |
| Uniprot: | Q15120 |
| Entrez: | 5165 |
Family
| Belongs to: |
|---|
| PDK/BCKDK protein kinase family |
Alternative Names
EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 3; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase kinase, isozyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Molecular Weight
Mass (kDA):
46.939 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.11 |
| Sequence: | X; NC_000023.11 (24465286..24550466) |
Tissue Specificity
Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hyperglycemia
- Hypoxia
- Diabetes Mellitus
- Myocardial Ischemia
- Melanoma
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Benign Prostatic Hypertrophy
- Insulin Resistance
Interacting Proteins
- DLAT
Pathways
- Glycolysis
- Insulin Secretion
- Secretion
- Pyruvate Oxidation
- Response To Starvation
- Drug Resistance
- Transport
- Cell Proliferation
- Tricarboxylic Acid Cycle
- Electron Transport
- Response To Lipid
- Cellular Senescence
- Aging
PTMs
- Phosphorylation
- Oxidation
- Acetylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDK3
bosterbio.com/bosterbio-gene-info-cards/PDK3
References
PMID: 7499431 by Gudi R., et al. Diversity of the pyruvate dehydrogenase kinase gene family in humans.
PMID: 10748134 by Baker J.C., et al. Marked differences between two isoforms of human pyruvate dehydrogenase kinase.