PHAX Antibodies

AND PHAX ELISA kits, PHAX Proteins

Many biological assays use antibodies to detect PHAX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHAX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHAX antibodies...

We validate the specificity of these antibodies to PHAX by testing them on tissues known to express PHAX positively and negatively. Browse below to find the PHAX antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHAX Infographic by Boster Bio

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PHAX (NM_032177) Human Over-expression Lysate

Human

$628
Cat # LS051808
20 µg, 100 µg

PHAX Overview

Facts about Phosphorylated adapter RNA export protein.

PHAX 3D structure. Source: alphafold

Phosphorylated adapter RNA export protein (PHAX)

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its lively GTP-bound form along with the export receptor XPO1 on the other.

Its phosphorylation in the nucleus is needed for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It's recycled back into the nucleus through the importin alpha/beta heterodimeric import receptor.

Gene Information

Human
Gene Name:	PHAX
Uniprot:	Q9H814
Entrez:	51808

Family

Belongs to:

PHAX family

Alternative Names

FLJ13193; phosphorylated adapter RNA export protein; phosphorylated adaptor for RNA export; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor (phosphorylation regulated); RNUXA

Molecular Weight

Mass (kDA):
44.403 kDA

Genomic Context


Human

Location:	5q23.2
Sequence:	5; NC_000005.10 (126600947..126627252)

Subcellular Localizations

Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.

Diseases

Neurodegenerative Disorders
Muscular Atrophy
Atrophy
Spinal Muscular Atrophy

Pathways

Nuclear Export
Transport
Localization
Rna Interference
Ribosome Biogenesis
Nucleocytoplasmic Transport
Nuclear Import

Rna Processing
Snorna Processing

PTMs

Phosphorylation

Dephosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHAX

References

PMID: 15574332 by Boulon S., et al. PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.

PMID: 11333016 by Segref A., et al. The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export.