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- Table of Contents
Plectin Antibodies
AND PLEC ELISA kits, Plectin Proteins
Many biological assays use antibodies to detect Plectin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plectin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plectin antibodies...
Designing a Western blot for Plectin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PLEC Western Blot GuidePLEC Infographic by Boster Bio
All PLEC Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A06656-3
100 μg/vial
Cat # A06656-3
100 μg/vial
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02434-3
100 µg/vial
Cat # A02434-3
100 µg/vial
Human, Mouse
ELISA
$480
Cat # EKC1656
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1656
1 kit, containing one 96-well plate and all necessary reagents
PLEC Overview
Facts about Plectin.
Plectin (PLEC)
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle.
May be involved not only in the filaments network, but also in the regulation of the dynamics. Structural component of muscle.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLEC |
| Uniprot: | Q15149 |
| Entrez: | 5339 |
Family
| Belongs to: |
|---|
| plakin or cytolinker family |
Alternative Names
EBS1; HD1; Hemidesmosomal protein 1; LGMD2Q; PCNplectin 1, intermediate filament binding protein, 500kD; PLEC1b; PLEC1EBSO; plectin 1, intermediate filament binding protein 500kDa; plectin; plectin-1; PLTNepidermolysis bullosa simplex 1 (Ogna)
Molecular Weight
Mass (kDA):
531.791 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (143915153..143976800, complement) |
Tissue Specificity
Widely expressed with highest levels in muscle, heart, placenta and spinal cord.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.
Diseases
- Epidermolysis Bullosa
- Muscular Dystrophy
- Dystrophy
- Bulla
- Tissue Adhesions
- Bullous Pemphigoid
- Glioma
- Myopathy
- Malignant Neoplasms
- Dental Plaque
- Neoplasms
Interacting Proteins
- FUS
- ITGB4
Pathways
- Localization
- Cell Adhesion
- Wound Healing
- Translation
- Pathogenesis
- Cell Migration
- Proteolysis
- Hemidesmosome Assembly
- Cytoskeleton Organization
- Cell Motility
- Mitosis
- Cell-matrix Adhesion
- Cellular Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEC
bosterbio.com/bosterbio-gene-info-cards/PLEC
References
PMID: 8633055 by Liu C.-G., et al. Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).
PMID: 8698233 by McLean W.H.I., et al. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.