Plectin Antibodies

Plectin (PLEC)

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle.

May be involved not only in the filaments network, but also in the regulation of the dynamics. Structural component of muscle.

Gene Information

Human
Gene Name:	PLEC
Uniprot:	Q15149
Entrez:	5339

Family

Belongs to:
plakin or cytolinker family

Alternative Names

EBS1; HD1; Hemidesmosomal protein 1; LGMD2Q; PCNplectin 1, intermediate filament binding protein, 500kD; PLEC1b; PLEC1EBSO; plectin 1, intermediate filament binding protein 500kDa; plectin; plectin-1; PLTNepidermolysis bullosa simplex 1 (Ogna)

Molecular Weight

Mass (kDA):
531.791 kDA

Genomic Context

Human
Location:	8q24.3
Sequence:	8; NC_000008.11 (143915153..143976800, complement)

Tissue Specificity

Widely expressed with highest levels in muscle, heart, placenta and spinal cord.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.

Diseases

• Epidermolysis Bullosa
• Muscular Dystrophy
• Dystrophy
• Bulla
• Tissue Adhesions
• Bullous Pemphigoid
• Glioma
• Myopathy
• Malignant Neoplasms
• Dental Plaque
• Neoplasms

• Atresia
• Carcinoma
• Dermatologic Disorders
• Weakness
• Muscle Weakness
• Paraneoplastic Syndromes

Interacting Proteins

• FUS
• ITGB4

Pathways

• Localization
• Cell Adhesion
• Wound Healing
• Translation
• Pathogenesis
• Cell Migration
• Proteolysis
• Hemidesmosome Assembly
• Cytoskeleton Organization
• Cell Motility
• Mitosis
• Cell-matrix Adhesion
• Cellular Localization

• Angiogenesis
• Transport
• Hyperphosphorylation
• Catagen
• Keratinocyte Differentiation
• Rna Transport
• Cell Cycle

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEC

Best Uses Of The PLEC Marker

The PLEC Marker is a versatile biomarker, allowing researchers to utilize it for a variety of purposes. Scientists can utilize it to test samples of specific species as well as other applications. Boster scientists can also receive credits for their research. This biomarker can be used by scientists all over the world. Learn how to utilize it.

Anti-Bax

A longer PFS is related to low levels of Smac, Bak, and Bax in metastatic melanoma. These proteins could be of clinical value in predicting PFS. The area under receiver operating characteristic curve was 0.79. The combination of these markers has been utilized to identify patients who have better prognosis and improved PFS. This marker is an excellent biomarker in the metastatic setting and is currently being investigated to determine its clinical significance.

A recent study found that patients with low Bax expression had a better prognosis overall when compared to patients who had higher levels of Bak or Smac expression. This was the case across all cohorts. Patients with lower levels of mRNA for their tumors had better outcomes than those with higher levels. However, these findings are not gospel; further studies are required to confirm the latest findings. Once the PLEC marker can be used to make predictions about patient prognosis, there are numerous possibilities for applications.

The three protein markers Bax, Bak, and Smac exhibit robust signatures for their specificity. Furthermore, the anti-BAX G317-2 antibody resolved activated and inert forms of BAK and BAX protein. These markers are used in clinical trials to evaluate the prognosis and survival of patients. Although they have been utilized extensively in clinical trials, these are not the only examples of anti-Bax immunotherapy.

In the metastatic setting, anti-Bax is associated with poor prognosis. The low expression of Bax or Bak could play a role in tumor formation and progression. It could also reduce susceptibility to apoptosis basal which dacarbazine based treatment could overcome. It is essential to be aware that the PLEC marker is not a replacement for medical treatment.

Anti-Glycophorin A / CD235a

CD235a is a single-pass membrane glycoprotein that is expressed on the erythrocytes, precursor cells and erythrocytes. It creates mucin-like barriers that may minimize aggregation of red blood cells in the circulation. Research has shown that CD235a may also act as an antiparvovirus receptor. Sandei virus and Streptococcus adhesins. This antibody is not intended to be used for diagnostic procedures or for resale.

Boster used two methods to confirm the antibody: retrovirally labeled CD235a and CFSE-labeled human EBs. Both methods resulted in very high levels of human CD235a cells in the spleen. The cells were located in larger CD235a cells. This could be due to phagocytosis by murine microphages.

Boster uses flow cytometry to examine cells stained by CD235a antibody. In the MACSQuant(r) Analyzer, data from the flow cytometry studies are examined. Tandem Signal Enhancer could also be used to increase the specificity of binding for tandem-dye conjugates. The results from the analyzed cells are processed with a tebu-bio software program.

Infection with CD34+ cells results is an important decrease in the percentage of enucleated cells. GPA-VNA/A did not alter the growth rate. The presence of this protein in cultured cells is a strong indication of the development of tumors. It is also required for immune surveillance. Effective tumor immunotherapy is dependent on the expression of CD235a.

Anti-Plectin

Plactin or PLEC, is a protein with a kD of 500kD. It acts as an interlinker between filamentous actin, intermediate filaments, and the cytoskeleton. The molecule of plectin is able to bind actin and spectrin-repeats on its surface. It also serves as a scaffold for signaling molecules, including protein kinase C receptors as well as non-receptor tyrosine Fer.

Recent research suggests that patients with lung cancer with high levels of plectin expression are less likely to survive than those who have lower levels. Patients with lung adenocarcinoma have a lower chance of survival if they have high levels of plectin. This is a risk ratio (2.2) and a P-value (5.5e-11). This may be due to the role of plectin in tumorigenesis. People who have lung cancer who don't smoke are more likely than those who do to live.

Plectin is one of four isoforms each with distinct N-terminal sequences. Mutations in PLEC result in distinct phenotypes and first-exon sequences. The gene that encodes plectin is believed to have been linked to a variety of forms of cancer and could represent an exciting therapeutic target for the treatment of various cancers. This marker can be used in many ways in clinical practice. It is currently a highly effective biomarker for research and diagnostics.

In addition to its role in the development of cancer It is also involved in movement and invasion of various types of cancers, such as breast cancer and CSCs. The reduction of plectin levels in human cells resulted in decreased colony formation and lower migration. Additionally it has been proven that a specific gene in plectin has characteristics reminiscent of CSCs. It is also believed to be an effective therapeutic target for CSC detection and cancer prevention.

The mice lacking plectin have normal HD assembly. This suggests that the rod domain plays a part during dynamic turnover of HDs. This is essential for keratinocyte migration and wound healing. The rodless plectin mouse was treated with four full-thickness excisions and were scored on the length of their epidermal lips at day three after healing.

PLEC Marker

The PLEC marker is a tool used in a variety of medical procedures. This protein, which is produced by many tissues in the body, interacts with intermediate filaments, which form networks of strength and support. Plectin is present in a variety of tissues, not just the skin. Although its role in the body isn't fully understood the possibility is that it plays an important role in prevention or treatment of epidermolysis bullosa.