PLEKHO1 Antibodies

AND PLEKHO1 ELISA kits, PLEKHO1 Proteins

Many biological assays use antibodies to detect PLEKHO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHO1 antibodies...

We validate the specificity of these antibodies to PLEKHO1 by testing them on tissues known to express PLEKHO1 positively and negatively. Browse below to find the PLEKHO1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHO1 Infographic by Boster Bio

All PLEKHO1 Products

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Product

Figures

Specificity

Applications

Price

Anti-CKIP1 PLEKHO1 Antibody

Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 μg/mL

Human, Mouse, Rat

ELISA, WB

$481
Cat # A06065
0.1 mg

PLEKHO1 (NM_016274) Human Recombinant Protein

Coomassie blue staining of purified PLEKHO1 protein

$1249
Cat # PROTQ53GL0
20 µg

PLEKHO1 (NM_016274) Human Over-expression Lysate

Human

$628
Cat # LS051177
20 µg, 100 µg

PLEKHO1 Overview

Facts about Pleckstrin homology domain-containing family O member 1.

PLEKHO1 3D structure. Source: alphafold

Pleckstrin homology domain-containing family O member 1 (PLEKHO1)

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to goal CK2 to the plasma membrane thereby functioning as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2).

Appears to target ATM into the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival.

Gene Information

Human
Gene Name:	PLEKHO1
Uniprot:	Q53GL0
Entrez:	51177

Family

Belongs to:

No superfamily

Alternative Names

2810052M02Rik; Casein kinase 2-interacting protein 1; C-Jun-binding protein; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; CKIP1; CKIP-1PH domain-containing family O member 1; JBP; OC120; Osteoclast maturation-associated gene 120 protein; pleckstrin homology domain containing, family O member 1; pleckstrin homology domain-containing family O member 1

Molecular Weight

Mass (kDA):
46.237 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (150149434..150160065)

Tissue Specificity

Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate (PubMed:14729969). In C2C12 cells, with the absence of growth factor, it is found in the nucleus (PubMed:14729969). It rapidly translocates to the plasma membrane after insulin stimulation (PubMed:14729969). In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3 (PubMed:15706351). However, the subcellular location is highly dependent of the cell t

Diseases

Osteoporosis

Interacting Proteins

PSMC5
SMURF1

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHO1

References

PMID: 10799509 by Bosc D.G., et al. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.

PMID: 15706351 by Zhang L., et al. Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.