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- Table of Contents
Facts about Calcineurin subunit B type 1.
.
Human | |
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Gene Name: | PPP3R1 |
Uniprot: | P63098 |
Entrez: | 5534 |
Belongs to: |
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calcineurin regulatory subunit family |
Calcineurin B; calcineurin subunit B type 1; CALNB1; CNA2; Cnb1; MCIP1; PP2B beta 1; PPP3R1; Protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform(calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform(calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 3 regulatory subunit B alpha isoform 1; protein phosphatase 3, regulatory subunit B, alpha; type I (19kDa)
Mass (kDA):
19.3 kDA
Human | |
---|---|
Location: | 2p14 |
Sequence: | 2; NC_000002.12 (68178857..68252532, complement) |
Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Cell membrane; Lipid-anchor. Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.
This article will discuss the uses of PPP3R1 markers. We will examine the use of the PPP3R1 Marker to detect fibrosis, and how it can be combined with other markers. This article will provide advice and tips for assessing the efficacy of this marker in different clinical applications. Continue reading for more information! Boster Bio: Best Uses of The PPP3R1 marker
These are some of the best uses that the PPP3R1 marker can be made in cancer research
There are many markers that can determine if the patient has a specific type of fibrosis. This panel includes PPP3R1, COLEC11, GDF15, and THBS2. The fibrosis markers are also indicative of a person's BMI, albumin, and ALT levels. It is not known if PPP3R1 is a reliable marker for fibrosis.
The diagnostic signature can easily be determined by detecting at minimum one of the markers in Tables 3-3, 4-6, and 8-10. These markers can be associated with advanced liver dysfunction and NASH. Detection of the signature can help physicians and patients manage medical resources. The PPP3R1 marker can be used to predict the progression and severity of liver fibrosis.
Advanced markers are also available. This panel includes markers listed in Tables 6, 8, 10 and 10 of NASH blood test. It is sensitive and specific to about 80% when used in conjunction other biomarkers. The degree of fibrosis affects the accuracy of this marker. High levels of PPP3R1 can indicate advanced stages.
The present invention consists of a diagnostic panel to detect liver fibrosis and NASH risk assessment. It also monitors treatment for advanced liver disease. The panel contains a specific reagent for the detection of one of the fibrosis marker in Tables. A set of instructions for obtaining diagnostic information based on the PPP3R1 marker can be provided.
Genetic variants in the PPP3R1 gene are related to cardiac hypertrophy in humans. The CARDIGENE Study and Glasgow Heart Scan Study have looked at the genetic variations associated with calcineurin. These studies indicate that these polymorphisms might be important for cardiac hypertrophy. These genes are still being studied in detail to determine their exact role in human cardiac disease.
The activity of this enzyme can only be determined if the cell contains at least two of the following genes. The PPP3R1 gene encoding okadaic acid and the PPP3R1 gene are involved in phosphate transport. The enzymes include conserved metal coordination residues and catalytic elements. The most important of these enzymes is PP3R1.
PPP3R1 variants may increase the amount of tau protein in cerebrospinal water and accelerate the progression AD. A previous study found that genetic variations in this gene were associated to a higher rate of cognitive decline. These findings were repeated in the Cache County Dementia Progression Study. This study however uses a larger sample size of patients with AD-onset early.
These polymorphisms are located in the PPP3CA (N352N), GATA4 and GATA4 respectively (S377G). These genes are located on chromosome 2. CPP3R1 genes are located at 9q31.1. The PPP3CB gene contains the S377G, GATA4/A411V and S377G polymorphisms.
Recently, five CRC immune genes were identified in a study that could be used to identify diagnostic biomarkers. Five candidate genes were identified by the authors, whose expression was associated with a poorer prognosis. These genes include PPP3R1 and APP. PSME4 was associated with poor prognosis. The authors conclude, therefore, that the PPP3R1 genes may be a potential target for immunotherapy of CRC.
PPP3R1 also known as calcineurin b. This protein phosphatase is under the control of Ca2+/calmodulin. It is a heterodimer, consisting of the Ca2+ binding regula b subunit and catalytic asubunit. There are three members in the CaN gene family. PPP3R is one. These markers were found to be associated with colorectal carcinomas, including melanomas and adenocarcinomas.
The PPP3R1 mutation is a novel marker that identifies intestinal immunity in humans. These studies will allow us to better understand intestinal immunity. However, many questions remain about its clinical utility. This marker can be used to identify people with specific genetic conditions. You can read more about its potential clinical application below. This article will discuss its basic characteristics and its potential clinical applications.
PMID: 2558868 by Guerini D., et al. Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
PMID: 12809556 by Genesca L., et al. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.