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- Table of Contents
Protein kinase C eta type Antibodies
AND PRKCH ELISA kits, Protein kinase C eta type Proteins
Many biological assays use antibodies to detect Protein kinase C eta type, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein kinase C eta type in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein kinase C eta type antibodies...
Designing a Western blot for Protein kinase C eta type? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRKCH Western Blot GuidePRKCH Infographic by Boster Bio
All PRKCH Products
Product
Figures
Specificity
Applications
Price
Anti-PKC eta/PRKCH Antibody Picoband®
1 Citations
Human
Flow Cytometry, IHC, ICC, WB
$370
Cat # PB9556
100 μg/vial
Cat # PB9556
100 μg/vial
PRKCH Overview
Facts about Protein kinase C eta type.
Protein kinase C eta type (PRKCH)
Calcium-independent, phospholipid- and diacylglycerol (DAG)-reliant serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation.
Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, resulting in RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKCH |
| Uniprot: | P24723 |
| Entrez: | 5583 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.13; nPKC-eta; PKCLMGC26269; PKC-LMGC5363; PRKCLprotein kinase C eta type; protein kinase C, eta
Molecular Weight
Mass (kDA):
77.828 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q23.1 |
| Sequence: | 14; NC_000014.9 (61187305..61550980) |
Tissue Specificity
Most abundant in lung, less in heart and skin.
Subcellular Localizations
Cytoplasm.
Diseases
- Cerebrovascular Accident
- Infarction
- Lacunar Infarction
- Ischemic Stroke
- Hypertensive Disease
- Hemorrhage
- Rheumatoid Arthritis
- Arthritis
- Brain Infarction
- Cerebral Infarction
- Dysequilibrium Syndrome
- Inflammation
Pathways
- Pathogenesis
- Aging
- Methylation
- Dna Hypomethylation
- Dna Methylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKCH
bosterbio.com/bosterbio-gene-info-cards/PRKCH
References
PMID: 1986216 by Bacher N., et al. Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
PMID: 7988719 by Palmer R.H., et al. Identification of multiple, novel, protein kinase C-related gene products.
2 Publications of Boster Protein kinase C eta type Antibodies & ELISA Kits
- PubMed ID: 10.2147/DDDT.S93570, 5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): ...
- PubMed ID: 26937173, 5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): ...
*More publications can be found for each product on its corresponding product page