Serine/threonine-protein kinase D2 (PRKD2)

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the term of MAPK1/3 (ERK1/2) signaling, which contributes to accumulation of immediate-early gene products such as FOS that stimulate cell cycle progression (By similarity).

In response to oxidative stress, is phosphorylated in Tyr-438 and Tyr-717 by ABL1, which contributes to the activation of PRKD2 without raising its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated in Ser-244 by CSNK1D and CSNK1E, translocates into the nucleus, phosphorylates HDAC7, resulting in nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809).